不同疗程奥美拉唑治疗儿童消化性溃疡的效果对比

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Abstract Objective To compare the effect of Omeprazole for children with peptic ulcer in different courses of treatment.Methods Sixty pediatric patients admitted to our hospital from January 2016 to June 2017 were selected as subjects.According to C urea breath test(14C-UBT),the test results were classified into HelicobaCter pylori(Hp)positive group (n=40)and HP negative group (n=20).In the Hp negative group,they were further divided into group A and group B with 10 cases in each group.In the Hp positive group,they were also further divided into group C and group D with 20 cases in each group.For Hp negative group,oral administration of Omeprazole for 2 weeks in group A was performed,while 4 weeks in group B.For Hp positive group,children in group C were given Omeprazole,Amoxicillin Clavulanate Potassium and Clarithromycin for 2 weeks.After treatment with Omeprazole,Amoxicillin Clavulanate Potassium and Clarithromycin for 2 weeks in group D,antibiotics were discontinued and Omeprazole was continued for 2 weeks.The Hp-positive group and the Hp negative group were all examined in our hospital after stopping the drug for 4 weeks.The Hp positive group was also tested by14C-UBT.The total effective rate of treatment and the incidence of adverse drug reactions were compared between two groups and14C-UBT in Hp positive group was compared.Results There were no significant differences in the total effective rate of treatment and the incidence of adverse drug reactions between group A and group B(P>0.05).There were no significant differences in the total effective rate of treatment and the incidence of adverse drug reactions between group C and group D (P>0.05).There was no significant difference in 1 4 C-UBT between group C and group D (P>0.05).Conclusion The study intends to provide a short course of treatment for children with peptic ulcer by comparing the comprehensive curative effect of 2 weeks and 4 weeks,increasing compliance,reducing side effects of drugs,and reducing economic burden for children′s parents,which has good social and economic benefits.

Key words： Children Peptic ulcer Hp positive group Hp negative group

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	JIANG Ling
	LIU Xiao-ming

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JIANG Ling,LIU Xiao-ming. Effect comparison of Omeprazole for children with peptic ulcer in different courses of treatment[J]. 中国当代医药, 2018, 25(28): 119-121.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I28/119

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