重型颅脑损伤后脑脊液内GFAP蛋白的变化及其与颅内压的相关性研究

Abstract
Figure/Table
References (15)
Related Citation (15)

Download: PDF (0 KB) HTML (34 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the changes of serum glial fibrillary acidic protein (GFAP)in cerebrospinal fluid(CSF)after severe craniocerebral injury and its correlation with intracranial pressure,so as to provide a basis for improving the diagnosis and treatment of severe craniocerebral injury.Methods A total of 42 cases of severe craniocerebral injury treated in our hospital from October 2016 to August 2017 were selected as the experimental group,and 42 cases of healthy physical examination or volunteers were selected as the control group.The cerebrospinal fluid samples were extracted from 6,12,24,48 and 72 h after injury,and the level of GFAP protein was detected,and the changes of intracranial pressure were monitored continuously,and the level of GFAP protein and intracranial pressure were compared with that of the intracranial pressure.At the same time,the correlation between the change of GFAP protein and the intracranial pressure at each time point after injury in the study group were analyzed.Results①The level of GFAP protein in cerebrospinal fluid in the experimental group was significantly higher than that of the control group(P<0.05）,and the 24 h reached the peak value in the experimental group after brain injury and decreased with the time.②The intracranial pressure increased immediately after injury in the experimental group,and the intracranial pressure at all time points was significantly higher than that of the control group(P<0.05）.The peak of intracranial pressure in the experimental group occurred at 48 h after injury,and the intracranial pressure remained at a high level after 48 h.③The intracranial pressure and cerebrospinal fluid GFAP protein in the experimental group showed an upward trend and a positive correlation (r=6.483,P<0.05）.ConclusionAfter severe craniocerebral injury,GFAP protein and intracranial pressure in cerebrospinal fluid are elevated,and their changes in early stage are consistent.The detection of GFAP protein and intracranial pressure in cerebrospinal fluid can be used for clinical diagnosis,to grasp the evolution of the disease and to provide reference for the treatment.

Key words： Craniocerebral injury Cerebrospinal fluid GFAP protein Intracranial pressure

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	TU Yao-ran
	NIU Fan
	HONG De-quan

Cite this article:

TU Yao-ran,NIU Fan,HONG De-quan. Changes of GFAP protein in cerebrospinal fluid after severe craniocerebral injury and its correlation with intracranial pressure[J]. 中国当代医药, 2018, 25(28): 39-41.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I28/39

[1]	陈红霞.针对性气道护理对重症颅脑损伤患者排痰效果及VAP发生率的影响[J].保健医学研究与实践，2015，12（2）：79-80.
[2]	吴毅.重症颅脑损伤后意识障碍的精准康复[J].中国康复医学杂志，2017，32（3）：249-252.
[3]	张剑，刘君，宋闰宇，等.TNF-α和IL-6对重症颅脑损伤后急性心肌功能损害的影响[J].河北医药，2017，39（22）：3400-3402.
[4]	管峥峰，狄剑秋，杨超，等.标准外伤大骨瓣开颅术治疗重型颅脑损伤的临床效果[J].实用临床医药杂志，2016，20（13）：96.
[5]	姚琳.丙泊酚对急性重型颅脑损伤患者的脑保护作用[J].新乡医学院学报，2016，33（9）：804-806.
[6]	冯昌允，戴秀华，董琰.惊厥患儿血清中GFAP及MBP的表达水平及临床意义[J].中国煤炭工业医学杂志，2016，19（2）：201-204.
[7]	王昊，杨华江，周椿，等.创伤性颅脑损伤后血清GFAP蛋白的变化与伤情及预后的Meta分析[J].创伤外科杂志，2017，19（6）：405-410.
[8]	祝善尧，葛伟，陈贵海.婴儿痉挛症患者血清、脑脊液S-100β和胶质纤维酸性蛋白水平观察及其相关性分析[J].山东医药，2017，57（35）：72-74.
[9]	李郭辉.重型颅脑损伤患者标准大骨瓣开颅术后颅内压监测的意义[J].神经损伤与功能重建，2016，11（6）：547-548.
[10]	王成东，武丽丽，王玉亭，等.S100B蛋白与颅脑损伤预后的关系[J].中国临床神经外科杂志，2005，10（1）：25-26.
[11]	刘洁，王婧，吴凡.重型颅脑损伤患者血肿清除术后持续颅内压监测及护理[J].实用临床医药杂志，2016，20（8）：154-155.
[12]	李鹏林，张强.中重型颅脑损伤脑脊液和血清S100B蛋白水平时间相关性研究[J].中国医学创新，2015，12（3）：10-12.
[13]	李秋松，陈翀，王保平，等.重型和特重型颅脑损伤患者伤后 1 周内颅内压变化特点[J].武警医学，2016，27（1）：40-42.
[14]	陈长春，柴妍楠，闫燕，等.缺氧缺血性脑病足月新生儿脑脊液中GFAP水平变化及意义[J].山东医药，2016，56（9）：60-61.
[15]	刘晓兰.TNF-α和IL-6与重型颅脑损伤后心肌功能相关性分析[J].中南医学科学杂志，2016，44（2）：192-194.