无创通气联合血液净化治疗对急性呼吸窘迫综合征患者炎症因子与氧化应激反应的影响

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Abstract Objective To study the influence of non-invasive ventilation combined with blood purification on inflammatory factors and oxidative stress in patients with acute respiratory distress syndrome.Methods All of 78 patients with acute respiratory distress syndrome admitted into our hospital from January 2015 to May 2017 were selected as the study subjects.They were divided into the control group(n=39)and observation group(n=39)according to the random number table method.The control group was treated with non-invasive ventilation,and the observation group was treated with non-invasive ventilation combined with blood purification.The levels of inflammatory factors and oxidative stress reaction indexes were compared between the two groups.Results After treatment,the levels of TNF-α,IL-1β and IL-6 inflammatory factors in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The CRP level in the observation group was higher than that in the control group,and the degree of reduction of SOD and GSH-Px in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The increase of MDA in the observation group was lower than that in the control group (P<0.05).Conclusion non-invasive ventilation combined with blood purification treatment for patients with acute respiratory distress syndrome can help to stabilize inflammatory factors and oxidative stress,ensure clinical efficacy,and promote the early recovery of patients,which is worthy of popularization and application.

Key words： Acute respiratory distress syndrome noninvasive ventilation Blood purification Inflammatory factors Oxidative stress response Efficacy

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	Articles by authors
	PU Yi-hua
	LI Jin-hua
	MENG Ji-shen
	ZHANG Xing-yu
	JIN Ming-gen

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PU Yi-hua,LI Jin-hua,MENG Ji-shen, et al. Influence of non-invasive ventilation combined with blood purification on inflammatory factors and oxidative stress in patients with acute respiratory distress syndrome[J]. 中国当代医药, 2018, 25(28): 21-24.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I28/21

[1]	中华医学会呼吸病学分会呼吸危重症医学学组.急性呼吸窘迫综合征患者机械通气指南（试行）[J].中华医学杂志，2016，96（6）：404-424.
[2]	孙耕耘.急性呼吸窘迫综合征柏林诊断标准：来自开胸肺活检的启示[J].中华肺部疾病杂志（电子版），2016，9（2）：117-119.
[3]	Shirole RL，Shirole NL，Saraf MN.Embelia ribes，ameliorates lipopolysaccharide-induced acute respiratory distress syndrome[J].J Ethnopharmacol，2015，168：356-363.
[4]	Nemer SN，Caldeira JB，Santos RG，et al.Effects of positive end-expiratory pressure on brain tissue oxygen pressure of severe traumatic brain injury patients with acute respiratory distress syndrome： a pilot study[J].J Crit Care，2015，30（6）：1263-1266.
[5]	黄万秀，陈红梅，邓太兵.喷他佐辛联合咪达唑仑对ARDS机械通气患者呼吸力学及血流动力学的影响[J].热带医学杂志，2015，15（2）：227-230.
[6]	卢松，赵佩，赵丽丽，等.大承气汤辅助治疗ARDS患者对其pH、PaO2/FiO2和氧化应激状态的影响[J].现代生物医学进展，2017，23（28）：5501-5504.
[7]	Kan'O T，Kamijo Y，Hattori J，et al.Refractory status epilepticus，circulatory collapse after cardiac arrest，and acute respiratory distress syndrome caused by severe isolated fluvoxamine poisoning：a case report[J].Acute Med Surg，2015，2（1）：53-55.
[8]	Yuan H，Chen S，Hu F，et al.Efficacy of two combinations of blood purification techniques for the treatment of multiple organ failure induced by wasp stings[J].Blood Purif，2016，42（1）：49-55.
[9]	陈莹.无创正压通气治疗在重度哮喘合并呼吸衰竭患者的急诊抢救效果观察[J].中国民康医学，2016，28（16）：45-46.
[10]	Hongyan X，Weijiang X，Bin L，et al.Effects and risks of hypothermia during blood purification in the treatment of postoperative cardiogenic shock in valvular heart diseases[J].Am J Obstet Gynecol，2015，27（12）：975-979.
[11]	Luo J.Clinical study on acute renal failure treated with continuous blood purification[J].J Artif Organs，2016，5（4）：302-306.
[12]	Masip J，Peacock WF，Price S，et al.Indications and practical approach to non-invasive ventilation in acute heart failure[J].Eur Heart J，2017，39（1）：17-25.
[13]	钟俊，杨国辉.急性呼吸窘迫综合征机械通气患者呼出气冷凝液中过氧化氢和白介素-6含量变化的研究[J].贵州医药，2015，39（6）：549-551.
[14]	季明霞，斯小水，何建新，等.乌司他丁联合持续血液净化治疗对急性呼吸窘迫综合征患者肺血管内皮通透性的影响研究[J].中国全科医学，2015，18（6）：688-691.
[15]	祁雨，孟更图亚，张慧敏，等.持续气道正压通气治疗对阻塞性睡眠呼吸暂停综合征患者预后的影响[J].中华心血管病杂志，2016，44（2）：144-149.
[16]	Pilar J，Modesto IAV，Lopezfernandez YM，et al.High-flow nasal cannula therapy versus non-invasive ventilation in children with severe acute asthma exacerbation：An observational cohort study[J].Med Intensiva，2017 ，41（7）：418-424.
[17]	张伟，张加强，孟凡民.右美托咪定联合持续气道正压通气对食管癌根治术老年病人单肺通气时肺组织氧化应激反应及炎性反应的影响[J].中华麻醉学杂志，2014，34（1）：5-8.
[18]	肖斌.经鼻持续气道正压通气对阻塞性睡眠呼吸暂停低通气综合征伴高血压患者氧化应激反应、血管内皮功能及血压的影响[J].中国医学前沿杂志（电子版），2015，7（9）：60-63.
[19]	任珏辉，陈建荣，黄磊，等.ARDS患者呼出气冷凝液和血清中NO、ET-1和8-isoPG检测的临床意义[J].海南医学，2016，27（24）：4023-4026.
[20]	Christensen HM，Titlestad IL，Huniche L.Development of non-invasive ventilation treatment practice for patients with chronic obstructive pulmonary disease：Resultsfrom a participatory research project[J].SAGE Open Med，2017，5（35）：20-50.
[21]	魏铭，钟强，甄海宁，等.乌司他丁联合连续性血液净化治疗急性呼吸窘迫综合征48例[J].医药导报，2015，34（7）：910-913.
[22]	陈建，庞飞.持续血液净化治疗重症胰腺炎合并急性呼吸窘迫综合征的疗效及对血清炎症因子含量的影响[J].中国煤炭工业医学杂志，2015，18（10）：1679-1683.