亚胺培南治疗卒中相关性肺炎的临床效果

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Abstract Objective To analyze the clinical effect of Imipenem in the treatment of stroke-associated pneumonia.Methods A total of 90 patients with stroke-associated pneumonia admitted to the intensive care unit of department of respiratory medicine in our hospital from August 2015 to August 2017 were selected as study subjects.They were divided into the antibiotic group and the imipenem group according to the parity group method,with 45 cases in each group.Patients in the antibiotic group were treated with the corresponding antibiotics alone,and patients in the imipenem group were treated with Imipenem on the basis of antibiotic therapy.The time of normal temperature,antibiotic use,hospital stay,and the rate of bacterial clearance were compared between two groups.The results of laboratory test(white blood cell count[WBC],neutrophil count,C-reactive protein[CRP],procalcitonin[PCT])and scores of national institute of health stroke scale (NIHSS)before and after treatment were compared between two groups.Results After treatment,the body temperature returned to normal time in the imipenem group was(3.10±0.56)d,the antibiotic use time was(5.15±1.64)d,and the time of hospital stay was(11.30±3.21)d,which were significantly shorter than those in the antibiotic group([3.89±1.12]d,[7.12±1.35]d,[13.47±2.18]d),and the differences were statistically significant(P＜0.05).The rate of bacterial clearance in the imipenem group was 93.33%,which was higher than that in the antibiotic group(75.56%),and the difference was statistically significant(P＜0.05).The level of WBC in the imipenem group was(6.74±1.52)×103/L,the neutrophil count was(0.56±0.15),the level of CPR was(14.55±3.08)mg/L,and the level of PCT was(3.26±0.35)ng/ml,which were lower than those in the antibiotic group([10.47±4.26]×103/L,[1.01±0.12],[20.46±3.57]mg/L,[4.65±1.20]ng/ml),with statistically significant difference(P＜0.05).There was no significant difference in the score of NIHSS before treatment between two groups(P＞0.05).The NIHSS scores after treatment in two groups were significantly lower than those before treatment,and the differences were statistically significant(P＜0.05).The NIHSS scores after treatment in the imipenem group were(10.22±1.34)points,which were significantly lower than those in the antibiotic group([12.31±1.50]points),and the differences were statistically significant(P＜0.05).Conclusion The clinical effect of Imipenem in the treatment of stroke-associated pneumonia is definite.It can shorten the course of disease and time of hospitastay,effectively eliminate bacteria,which is worthy of clinical promotion and application.

Key words： Stroke Associated pneumonia Imipenem Antibiotics

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	Articles by authors
	WU Shan-yan
	WANG Qiang
	XIANG Zhi-qiang
	CHEN Xiao-fang

Cite this article:

WU Shan-yan,WANG Qiang,XIANG Zhi-qiang, et al. Clinical effiect of Imipenem in the treatment of stroke-associated pneumonia[J]. 中国当代医药, 2018, 25(25): 147-150.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I25/147

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