高血压脑出血神经外科手术后癫痫发作的影响因素分析

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Abstract Objective To explore the influencing factors of postoperative seizures after Department of Neurosurgery operation for hypertensive intracerebral hemorrhage.Methods A total of 58 cases of patients with hypertensive intracerebral hemorrhage of diagnosis treated in Department of Neurosurgery,the Third People′s Hospital of Shenzhen City from May 2016 to October 2017 were retrospective analyzed.They were divided into two groups according to whether they were epileptic seizures after operation.Among them,17 patients with postoperative seizures were selected as the observation group,and 41 patients without seizures were used as control group.The levels of NSE and inflammatory factors in the two groups were observed,and their clinical characteristics were statistically analyzed.Results There were no significant difference in age and sex between the two groups(P＞0.05).The hematoma volume,hematoma location,postoperative rebleeding and operative mode between the two groups were significant differences(P＜0.05).After operation,the levels of TNF-α,IL-6,CPR and NES in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P＜0.05).The results of multiple factor Logistic regression analysis showed that the position of hematoma,hematoma volume,and postoperative rebleeding,including serum inflammatory factor TNF-α,IL-6,CPR,NSE were independent risk factors for epileptic seizures after high hemorrhage of cerebral hemorrhage(P＜0.05).Conclusion The location of hematoma,hematoma volume and operation mode are independent risk factors for early onset epilepsy after intracerebral hemorrhage,and should be paid close attention in clinical practice.

Key words： Hypertensive intracerebral hemorrhage Seizure Neuron specific enolase Inflammatory factor

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	Articles by authors
	TANG Zhong
	CHEN Qi-fu
	LIAO Guang-sheng
	CHEN Si
	CHEN Jing-yu

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TANG Zhong,CHEN Qi-fu,LIAO Guang-sheng, et al. Influencing factors analysis of postoperative seizures in hypertensive intracerebral hemorrhage after Department of neurosurgery operation[J]. 中国当代医药, 2018, 25(25): 81-83转96.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I25/81

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