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| Clinical effect of clopidogrel in prevention of cardiovascular adverse events after coronary intervention |
| WANG Dan |
| Department of Cardiology,No.463 PLA Hospital in Shenyang City,Liaoning Province,Shenyang 110000,China |
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Abstract Objective To explore the preventive effect of clopidogrel on adverse cardiovascular events(ACEs)after interventional treatment of coronary heart disease (CHD).Methods Eighty-four CHD patients admitted to our hospital from July 2015 to January 2017 were selected as the subjects,and divided into two groups according to the doubleblinding,with 42 cases in each group.In control group,patients were treated with low molecular weight heparin,while in observation group,clopidogrel was provided.The activated partial thromboplastin time,thrombin time,prothrombin and fibrinogen time,post-treatment thromboxane B2level,incidence of ACEs,and treatment satisfaction were compared between the two groups.Results There was no significant difference in activated partial thromboplastin time,thrombin time,prothrombin or fibrinogen time between the two groups(P＞0.05).After 6,12 and 24-hour treatment,the thromboxane B2levels in the observation group were(82.22±14.85)ng/L,(65.13±12.52)ng/L,and(46.70±9.12)ng/L respectively,all lower than those in the control group for(93.15±16.49)ng/L,(75.42±15.01)ng/L and(66.91±11.04)ng/L(P＜0.05).The incidence of ACEs in the observation group was 4.76%,which was lower than that in the control group accounting for 26.18%,with a significant difference (P＜0.05).The treatment satisfaction from patients in the observation group was 97.62%,higher than that in the control group accounting for 78.57%,with statistical significance(P＜0.05).Conclusion The use of clopidogrel in interventional treatment of CHD has a significant effect on the prevention of ACEs.
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