伊伐布雷定联合持续性气道正压通气治疗阻塞性睡眠呼吸暂停低通气综合征合并心律失常的临床效果

Abstract
Figure/Table
References (21)
Related Citation (15)

Download: PDF (0 KB) HTML (41 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the clinical effect of Ivabradine combined with continuous positive airway pressure ventilation in the treatment of obstructive sleep apnea-hypopnea syndrome complicated with arrhythmia.Methods A total of 112 patients with obstructive sleep apnea-hypopnea syndrome with arrhythmia were treated in Huazhou People′s Hospital from March 2015 to April 2017 were selected.The patients treated with continuous positive airway pressure ventilation were selected as the control group,while the patients treated with Ivabradine combined with continuous positive airway pressure ventilation were selected as the observation group,and there were 56 patients in each group.The two groups were treated for 30 days.LAT,MAT,AHI,mSaO2,maximum heart rate,minimum heart rate,and arrhythmia rate were compared between the two groups.Results After treatment,the LAT,MAT,AHI,mSaO2,maximum heart rate,minimum heart rate,and arrhythmia rate in the two groups were improved compared with before treatment,and the differences were statistically significant(P＜0.05).After treatment,AHI of the observation group was significantly lower than that of the control group,mSaO2was significantly higher than that of control group,average arrhythmia rate was significantly lower than that of the control group,and the differences were statistically significant(P＜0.05).Conclusion The clinical effect of Ivabradine combined with continuous positive airway pressure ventilation in the treatment of obstructive sleep apnea-hypopnea syndrome with arrhythmia is more significant,and it can effectively improve the arrhythmia of the patients.

Key words： Obstructive sleep apnea-hypopnea syndrome Continuous positive airway pressure ventilation Ivabradine Arrhythmia

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YI Jing-de
	CHEN Hao

Cite this article:

YI Jing-de,CHEN Hao. Clinical effect of Ivabradine combined with continuous positive airway pressure ventilation in the treatment of obstructive sleep apnea-hypopnea syndrome complicated with arrhythmia[J]. 中国当代医药, 2018, 25(25): 57-59转62.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I25/57

[1]	单杨杨.不同程度老年阻塞性睡眠呼吸暂停综合征患者并发症对比及其治疗[J]．中国老年学杂志，2012，32（9）：1806-1808．
[2]	Antic NA，Catcheside P，Buchan C，et al.The effect of CPAP in normalizing daytime sleepiness，quality of life，and neurocognitive function in patients with moderate to severe OSA[J].Sleep，2011，34（1）：111-119.
[3]	倪灵凡.阻塞性睡眠呼吸暂停综合征合并与非合并缺血性心脏病患者3个月持续正压通气治疗后血脂参数的变化[J].中国老年学杂志，2014，34（19）：5421-5423.
[4]	凌敏，苟安栓，朱佳，等.持续正压通气对阻塞性睡眠呼吸暂停综合征心律失常的作用[J].新疆医学，2013，43（8）：29-32．
[5]	Yagmur J，Yetkin O，Cansel M，et al.Assessment of atrial electromechanical delay and influential factors in patients with obstructive sleep apnea[J].Sleep Breath，2012，16（1）：83-88．
[6]	中华医学会呼吸病学分会睡眠呼吸疾病学组.阻塞性睡眠呼吸暂停低通气综合征诊治指南（草案）[J].中华结核和呼吸杂志，2002，25（4）：195-198．
[7]	陆再英，钟南山.内科学[M]．7版.北京：人民卫生出版社，2008：182-236．
[8]	李正功，张勇，李涛平，等.阻塞性睡眠呼吸暂停低通气综合征患者免疫功能的损伤及相关机制[J].中华肺部疾病杂志（电子版），2011，4（4）：276-280．
[9]	景风敏，冯彩红，朱庆文，等.阻塞性睡眠低通气综合征患者生存质量分析[J].河北医药，2011，33（23）：3562-3563．
[10]	高兴林，袁平.阻塞性睡眠呼吸暂停低通气综合征治疗方法的选择[J].实用医学杂志，2014，30（24）：3889-3890.
[11]	Baranchuk A，Parfrey B，Lim L，et al.Interatrial block in patients with obstructive sleep apnea[J].Cardiol J，2011，18（2）：171-175．
[12]	孙龙凤，孔德磊，王爱平，等.电话随访对阻塞性睡眠呼吸暂停综合征患者使用正压通气依从性的影响[J].中华护理杂志，2012，47（2）：118-120.
[13]	Lizio G，Sterrantino AF，Ragazzini S，et al.Volume reduction of cystic lesions after surgical decompression：a computerised three-dimensional computed tomographic evaluation[J].Clin Oral Investig，2013，17（7）：1701-1708.
[14]	邱爽，杨波，平海芹，等.伊伐布雷定治疗窦性心动过速的 Meta 分析[J].疑难病杂志，2015，14（11）：1186-1190.
[15]	夏志高，言洁，朱幸仪.伊伐布雷定片对心力衰竭患者心功能及血清儿茶酚胺水平的影响[J].中国药业，2016，25（19）：20-23.
[16]	Lupi A，Rognoni A，Cavallino C，et al.Ivabradine for treatment ofcoronary artery disease：from last chance resort to main stem of areasoned therapy[J].Cardiovasc Hematol A-gents Med Chem，2015，13（1）：4-9.
[17]	Komajda M，Tavazzi L，Francq BG，et al.Efficacy and safety of ivabradine in patients with chronic systolic heart failure and diabetes：an analysis from the SHIFT trial[J].Eur J Heart Fail，2015，17（12）：1294-1301.
[18]	徐娜.CPAP呼吸机治疗阻塞型睡眠呼吸暂停综合征的疗效观察[J].中国医学创新，2013，10（32）：17-18.
[19]	盛红宇，李南方，周克明，等.短期持续气道内正压通气治疗对不同程度阻塞性睡眠呼吸暂停低通气综合征合并高血压患者的降压疗效比较[J].中华全科医师杂志，2015，14（6）：442-447.
[20]	杨娟，倪松石.持续气道内正压通气治疗阻塞性睡眠呼吸暂停低通气综合征合并缺血性心脏病的研究进展[J].中华老年多器官疾病杂志，2014，13（12）：957-960.
[21]	方明亮，李松桃，刘家勉，等.持续气道正压通气对合并阻塞性睡眠呼吸暂停的难治性高血压疗效的Meta分析[J].中国医药导报，2016，13（30）：175-179.