|
|
|
| Analysis of flora in type 2 diabetes mellitus complicated with lower respiratory tract infection |
| WANG Tong1 XIANG Hua-guo2 LIN Yu-ping3 ZHAO Ya-li4 GAO Dan5 |
| 1.Department of Infection,the Third People′s Hospital of Baoan People′s Hospital(Group)of Shenzhen City,Guangdong Province,Shenzhen 518103,China;2.Department of Central Laboratory,the Third People′s Hospital of Baoan People′s Hospital(Group)of Shenzhen City,Guangdong Province,Shenzhen 518103,China;3.Department of Pharmacy,the Third People′s Hospital of Baoan People′s Hospital(Group)of Shenzhen City,Guangdong Province,Shenzhen 518103,China;4.The Third Department of Internal Medicine,the Third People′s Hospital of Baoan People′s Hospital(Group)of Shenzhen City,Guangdong Province,Shenzhen 518103,China;5.Department of Clinical Laboratory,the Third People′s Hospital of Baoan People′s Hospital(Group)of Shenzhen City,Guangdong Province,Shenzhen 518103,China |
|
|
|
|
Abstract Objective To explore the flora characteristics of type 2 diabetes mellitus combined with lower respiratory tract infection.Methods A total of 120 patients with type 2 diabetes mellitus complicated with lower respiratory tract infection treated in our hospital from January 2015 to December 2017 were selected,and the identification and drug sensitivity test in 398 strains isolated from sputum of these patients were conducted using a Microscan Autoscan-4 microbiological analyzer.Results A total of 100 patients in 120 patients were positive in bacterial culture,and the positive rate of 83.33%(100/120).A total of 398 strains were isolated from sputum samples in 100 patients with positive bacterial culture,among them,367 strains were Gram-negative strains(accounting for 92.21%),and 31 strains were Grampositive strains(accounting for 7.79%).Stenotrophomonas maltophilia was naturally resistant to Imipenem.The resistance rate of the other 4 Gram-negative bacteria to Imipenem was 2.33%-15.3%.The detection rate of extended-spectrum beta-Lactamases(ESBLs)producing Escherichia coli,Klebsiella pneumoniae,methicillin-resistant Staphylococcus aureus(MRSA),multidrug-resistant Pseudomonas aeruginosa (MDR-PA)and multidrug-resistant Acinetobacter baumannii(MDR-AB)was 32.23%,66.67%,25.51%and 20.00%,respectively.Conclusion The bacteria in sputum for patients with type 2 diabetes mellitus complicated with lower respiratory tract infection is mainly Gram-negative bacteria,and their resistance to antibiotics is high,and appropriate antibiotics should be selected in the course of treatment.
|
|
|
|
|
|
| [1] |
杨伟东，李双月，江仁，等.全身麻醉术后下呼吸道感染相关影响因素分析[J].中华医院感染学杂志，2018，28（9）：1374-1376.
|
| [2] |
Bellinghausen C，Rohde GGU，Savelkoul PHM，et al.Viral-bacterial interactions in the respiratory tract[J].J Gen Virol，2016，97（12）：3089-3102.
|
| [3] |
孙殿静，代晓茹，刘晴晴，等.舒血宁联合哌拉西林/舒巴坦在2型糖尿病合并下呼吸道感染患者中的应用效果[J].中华医院感染学杂志，2017，27（10）：2229-2232.
|
| [4] |
王伟丽，吴晓慧，王书会，等.某三级甲等医院Ⅱ型糖尿病患者医院感染危险因素分析[J].中国消毒学杂志，2018，35（4）：286-288.
|
| [5] |
Ma X，Zhang YL，Ji Q，et al.Diagnostic criteria for diabetes in China:are we pushing too much beyond evidence?[J].Eur J Clin Nutr，2017，71（7）：812-815.
|
| [6] |
Colhoun HM，Ginsberg HN，Robinson JG，et al.No effect of PCSK9 inhibitor alirocumab on the incidence of diabetes in a pooled analysis from 10 ODYSSEY Phase 3 studies[J].Eur Heart J，2016，37（39）：2981-2989.
|
| [7] |
蒋茜，周蓉，刘迎，等.糖尿病肾病患者心血管疾病患病率及其影响因素分析[J].中国全科医学，2017，20（29）：3590-3595.
|
| [8] |
Norhammar A，Bodegard J，Nystrom T，et al.Incidence，prevalence and mortality of type 2 diabetes requiring glucoselowering treatment，and associated risks of cardiovascular complications：a nationwide study in Sweden，2006-2013[J].Diabetologia，2016，59（8）：1692-1701.
|
| [9] |
潘娟，张杰文，谢政权，等.中国糖尿病教育模式的研究现状[J].现代医院，2016，16（8）：1205-1207.
|
| [10] |
张沛峰.老年2型糖尿病患者发生严重低血糖的危险因素分析[J].现代医院，2017，17（4）：573-575.
|
| [11] |
Dereje M，Woldeamanuel Y，Asrat D，et al.Urinary tract infection among fistula patients admitted at Hamlin fistula hospital，Addis Ababa，Ethiopia[J].BMC Infect Dis，2017，17（1）：150-154.
|
| [12] |
黄文辉，侯幸赟，张亚坤，等.2型糖尿病患者不同剂量沙格列汀单药和联合治疗与上呼吸道感染发病风险相关性 Meta 分析[J].中国医院药学杂志，2016，36（19）：1674-1680．
|
| [13] |
王佳超，张劲松，孙文佳，等.小剂量胰岛素治疗对糖尿病大鼠脊髓N-甲基-D-天冬氨酸受体及其下游信使表达的影响[J].中华老年医学杂志，2016，35（4）：432-436.
|
| [14] |
Acosta S，Bjorck M，Wanhainen A.Negative-pressure wound therapy for prevention and treatment of surgical-site infections after vascular surgery[J].Br J Surg，2017，104（2）：e75-e84.
|
| [15] |
刘曙光，王晓岳.加巴喷丁联合胰岛素泵治疗2型糖尿病并发呼吸道感染的疗效及对血糖及TNF-α、IL-6的影响[J].实用临床医药杂志，2018，22（1）：38-41.
|
| [16] |
王远方.甘精胰岛素联合瑞格列奈治疗2型糖尿病临床疗效观察[J].中国现代医生，2018，56（8）：42-44.
|
| [17] |
张宇宁，吕星，郑浩，等.头孢米诺钠治疗糖尿病合并社区获得性下呼吸道感染的临床效果分析[J].中华医院感染学杂志，2016，26（17）：3948-3949，3962．
|
| [18] |
林凤平，李进杰，王丽，等.2型糖尿病肺部感染患者持续皮下胰岛素注射的应用效果分析[J].中华医院感染学杂志，2016，26（2）：335-337．
|
|
|
|
