老年急性白血病患者并发2型糖尿病的临床观察和预后分析

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Abstract Objective To explore the clinical features and prognosis of elderly patients with acute leukemia combined with type 2 diabetes mellitus.Methods A total of 35 elderly patients with acute leukemia combine with type 2 diabetes mellitus were treated in our hospital from January 2014 to December 2016 were selected and retrospectively analyzed.According to the blood glucose status during diagnosis and treatment,they were divided into the observation group (n=12,high blood glucose or fluctuating state)and control group(n=23,good blood glucose control).The fasting blood glucose (FBG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),triglyceride(TG)and serum uric acid(UA)and other diabetes mellitus related indexes during chemotherapy were compared between the two groups,and the difference of treatment effect,adverse reactions and long-term survival time were analyzed.Results The levels of FBG,TC,LDL-C and UA in the control group were lower than those in the observation group during chemotherapy,and the differences were statistically significant(P＜0.05),while there was no significant difference in the levels of HDL-C and TG between the two groups(P＞0.05).The effective rate of the control group(91.30%)was higher than that of the observation group(41.67%)(P＜0.05).Adverse reactions mainly included ketoacidosis,infection,nervous system symptoms,digestive system symptoms and leukopenia.The incidence of ketoacidosis(0.00%),infection(30.43%)and digestive system symptoms(13.04%)in the control group was lower than those in the observation group(25.00%,66.67%,50.00%)respectively,and the difference was statistically significant(P＜0.05).There were no significant difference in the incidence of other adverse reactions between the two groups(P＞0.05).The median survival time in the control group(13.5 months)was longer than that in the observation group(6.75 months)(P＜0.05).Conclusion The elderly patients with acute leukemia combined with type 2 diabetes should be paid attention to reduce blood glucose treatment,the patients with poor glycemic control have the characteristics of poor curative effect,high infection rate and poor prognosis.

Key words： Leukemia Diabetes Clinical observation Long-term efficacy Survival rate

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	HE Ji-xiang
	JIANG Yi-rong

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HE Ji-xiang,JIANG Yi-rong. Clinical observation and prognosis analysis of elderly patients with acute leukemia combined with type 2 diabetes mellitus[J]. 中国当代医药, 2018, 25(25): 27-30.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I25/27

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