气体信号传导分子与婴幼儿轻度轮状病毒性肠炎伴良性惊厥的关系研究

Abstract
Figure/Table
References (16)
Related Citation (1)

Download: PDF (0 KB) HTML (44 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the relationship between the change of nitric oxide(NO),nitric oxide synthase(NOS)and hydrogen sulfide (H2S)level in infants with mild Rotavirus enteritis accompanied with benign convulsions.Methods A total of 50 children diagnosed as mild Rotavirus enteritis accompanied with benign convulsion in Shenyang Children′s Hospital from September 2015 to April 2017 were selected as the observation group in Shenyang Children′s Hospital,and 50 children with simple mild Rotavirus enteritis were selected as the control group at the same time.The clinical features,routine laboratory tests,and NO,NOS,H2S changes in children of the two groups and convulsion characteristics of the observation group were observed.Results There was no significant difference in clinical characteristics,routine laboratory examination and NO level between the two groups(P＞0.05).The serum NOS level of the observation group was significantly higher than that of the control group,and the serum H2S level was significantly lower than that of the control group(P＜0.01).Conclusion The occurrence of mild rotavirus enteritis with benign convulsion is independent of NO level,and is related to NOS and H2S level,and it suggests that the incidence of benign convulsions in children with mild Rotavirus enteritis can be predicted by changes in serum NOS and H2S level.

Key words： Rotavirus enteritis Benign convulsion Serum nitric oxide Serum nitric oxide synthase Serum hydrogen sulfide

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	CHEN Rui-dan
	LI Na
	MU Ya-ping
	WANG Shuang
	LI Lun

Cite this article:

CHEN Rui-dan,LI Na,MU Ya-ping, et al. Relationship study of gas signal conducting molecules and mild Rotavirus enteritis accompanied with benign convulsions in infants[J]. 中国当代医药, 2018, 25(25): 19-22.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I25/19

[1]	Tate JE，Burton AH，Boschi-Pinto C，et al.Global,regional,and national estimates of Rotavirus mortality in children＜5 years of age，2000-2013[J].Clin Infect Dis，2016，62（2）：S96-S105.
[2]	Parashar UD，Burton A，Lanata C，et al.Global mortality associated with Rotavirus disease among children in 2004[J].J Infect Dis，2009，200（1）：S9-S15.
[7]	王瑜，秦俊，熊志英，等.枯草杆菌二联活菌颗粒对轮状病毒肠炎患儿血清甘露聚糖结合蛋白水平的影响[J].中国当代医药，2017，24（28）：117-119.
[10]	Forstermann U，Sessa WC.Nitric oxide synthases:regulation and function[J].Eur Heart J，2012，33（7）：829-837.
[13]	石凯丽，韩红，朱镭，等.血清一氧化氮及一氧化氮合酶体系与轻度胃肠炎合婴幼儿良性惊厥的相关性研究[J].中国药物与临床，2014，14（3）：290-292.
[3]	de Vries LS，Bearden D.Neurologic complications of Rotavirus in neonates：more common than we thought?[J].Neurology，2015，84（1）：13-14.
[4]	Kang B，Kim DH，Hong YJ，et al.Comparison between febrile and afebrile seizures associated with mild Rotavirus gastroenteritis[J].Seizure，2013，22（7）：560-564.
[5]	Verrotti A，Nanni G，Aqostinelli S，et al.Benign convulsions associated with mild gastroenteritis：a multicenter clinical study[J].Epilepsy Res，2011，93（2-3）：107-114.
[6]	Verrotti A，Tocco AM，Coppola GG，et al.Afebrile benign convulsions with mild gastroenteritis：a new entity?[J].Acta Neurol Scand，2009，120（2）：73-79.
[8]	Alfajaro MM，Cho KO.Evidences and consequences of extraintestinal spread of Rotaviruses in humans and animals[J].Virusdis，2014，25（2）：186-194.
[9]	CalabreseV,MancusoC，CalvaniM，etal.Nitricoxideinthecentral nervous system：neuroprotection versus neurotoxicity[J].Nat Rev Neurosci，2007，8（10）：766-775.
[11]	Caviedes A，Varasgodoy M，Lafourcade，C，et al.Endothelial nitric oxide synthase is present in dendritic spines of neurons in primary cultures[J].Front Cell Neurosci，2017，11：180.
[12]	Kawashima H，Inage Y，Ogihara M，et al.Serum and cerebrospinal fluid nitrite/nitrate levels in patients with Rotavirus gastroenteritis induced convulsion[J].Life Sci，2004，74（11）：1397-1405.
[14]	Yeom JS，Kim YS，Park JS，et al.Role of Ca2+homeostasis disruption in Rotavirus-associated seizures[J].J Child Neurol，2014，29（3）：331-335.
[15]	Kimura Y，Darguseh R，Schubert D，et al.Hydrogen sulfide protects HT22 neuronal cells from oxidative stress[J].Antioxid Redox Signal，2006，8（3-4）：661-670．
[16]	Whiteman M，Cheung NS，Zhu YZ，et al.Hydrogen sulphide;a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain?[J].Biochem Biophys Res Commun，2005，326（4）：794-798.