5岁以下喘息儿童血液中KL-6及PAI-1的变化及临床意义

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Abstract Objective To investigate the changes and clinical significance of KL-6 and Plasminogen activator inhibitor-1(PAI-1)in children with wheezing less than 5 years old.Methods A total of 198 children under 5 years of age with wheezing symptoms diagnosed and treated in our hospital from January 2015 to December 2016 were selected and randomly divided into API positive group(n=104)and API--negative group(n=94)according to API scoring criteria.Patients in the two groups were inhaled budesonide suspension and bricanyl at 1-4 weeks,and only treated with montelukast sodium orally at 4 weeks.the asthma symptom scores were recorded before treatment,4,8 and 12 weeks after treatment,and the expression levels of KL-6 and PAI-1 in blood were detected.Results There was no significant difference between KL-6 and PAI-1 in API negative group(P＞0.05).The expression of KL-6 and PAI-1 in API-positive group decreased with the treatment time(P＜0.05),and the expression of KL-6 and PAI-1 in API-positive group was significantly higher than that in API-negative group(P＜0.05).There was no significant difference in KL-6 and PAI-1 expression between the two groups at 12 weeks after treatment(P＞0.05).There was no significant difference in asthma symptom score between the two groups before treatment(P＞0.05).The symptom scores of asthma decreased significantly at 4,8 and 12 weeks after treatment,the difference was statistically significant(P＜0.05).The scores of asthma symptoms in API positive group were significantly lower than those in API negative group at 4 and 8 weeks after treatment,the difference was statistically significant(P＜0.05);there was no significant difference in the scores of asthma symptoms between the two groups at 12 weeks after treatment(P＞0.05).Conclusion The expression of KL-6 and PAI-1 in the asthmatic children less than 5 years old is in a dynamic state and associates with the symptom score of asthma.

Key words： Asthma Alveolar typeⅡ epithelial cell surface antigen Plasminogen activator inhibitor-1 Children

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	Articles by authors
	GUO Cai-yun
	ZHANG Jin-feng
	WEI Chu-hong
	YAO Long-yan
	SUN Yan-na

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GUO Cai-yun,ZHANG Jin-feng,WEI Chu-hong, et al. Changes and clinical significance of KL-6 and PAI-1 in the blood of children with wheeze less than 5 years old[J]. 中国当代医药, 2018, 25(10): 95-98.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I10/95

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