阿司匹林肠溶片联合氯吡格雷治疗冠心病心绞痛的临床效果

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Abstract Objective To explore the clinical effect of Aspirin Enteric-Coated Tablets combined with Clopidogrel in treatment of angina pectoris of coronary heart disease.Methods Altogether 94 cases of patients with angina pectoris of coronary heart disease who were treated in our hospital from January 2016 to October 2017 were selected as the subjects of this research and divided into observation group and control group according to the randomized number method,with 47 cases in each group.Patients in control group were treated only with Aspirin Enteric-Coated Tablets treatment,patients in the observation group were treated with Clopidogrel and Aspirin Enteric-Coated Tablets,the continuous medication was given for 4 weeks.The changes of angina pectoris symptom index,plasma fibrinogen,plasma viscosity and total blood viscosity levels were compared between the two groups before and after treatment.Results After treatment,the interval of angina attack was longer than before treatment,the number of attacks was less than before treatment,the duration was shorter than before treatment,and the differences were statistically significant(P＜0.05).The interval of angina attack of patients in the observation group was longer than that in the control group,the number of attacks of patients in the observation group was less than that in the control group,the duration of patients in the observation group was shorter than that in the control group,and the differences were statistically significant(P＜0.05).After treatment,the plasma fibrinogen,plasma viscosity and total blood viscosity were lower than before treatment,and the differences were statistically significant(P＜0.05).The plasma fibrinogen,plasma viscosity and total blood viscosity of the patients in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion Combination of application of Aspirin Enteric-Coated Tablets and Clopidogrel is effective in the treatment of angina pectoris.It can effectively improve the symptoms of angina pectoris and regulate plasma fibrinogen,plasma viscosity and whole blood viscosity level,which is worthy of clinical promotion and application.

Key words： Coronary heart disease Angina pectoris Aspirin Enteric-Coated Tablets Clopidogrel

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MA Di-hui. Clinical effect of Aspirin Enteric-Coated Tablets combined with Clopidogrel in treatment of angina pectoris of coronary heart disease[J]. 中国当代医药, 2018, 25(8): 149-151转154.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I8/149

[1]	Takishima I，Nakamura T，Hirano M，et al.Predictive value of serial assessment of endothelial function in chronic heart failure[J].Int J Cardiol，2012，158（3）：417-422.
[3]	闫洁，袁森.银杏蜜环口服溶液联合阿司匹林肠溶片和氯吡格雷治疗冠心病心绞痛的疗效观察[J].现代药物与临床，2016，12（10）：1575-1578.
[5]	谷洪燕，庞惠.硫酸氢氯吡格雷片与阿托伐他汀钙胶囊及养心氏片治疗冠心病PCI术后心绞痛的疗效[J].中国实用医刊，2016，11（15）：119-121.
[7]	穆瑞斌.曲美他嗪联合阿托伐他汀治疗冠心病心绞痛的临床疗效观察[J].中国现代医生，2014，52（3）：51-53.
[16]	徐菡，邸平，王珊珊，等.白介素-8、超敏 C-反应蛋白及血管性假血友病因子联合检测在冠心病患者中的应用[J].中国医学装备，2017，14（9）：78-81.
[2]	Wu L，Liu B，Hu N，et al.A prospective randomized controlled trial of domestic Clopidogrel and Aspirin in treatment with stable coronary artery disease[J].J Clin Report，2015，2（1）：10.
[4]	Skierczynska A，Beresewicz A.Demand-induced ischemia in volume expanded isolated rat heart：the effect of Dichloroacetate and Trimetazidine[J].J Physiol Pharmacol，2010，61（2）：153-162.
[6]	Wang M，Moran AE，Liu J，et al.Cost-effectiveness of optimal use of acute myocardial infarction treatments and impact on coronary heart disease mortality in China[J].Circ Cardiovasc Qual Outcomes，2014，7（1）：78-85.
[8]	Dong P，Wang L，Sun M，et al.Comparison of antithrombotic effect between Tirofiban and Urokinase in emergency percutaneous coronary intervention[J].Biomed Res，2016，27（4）：1195-1198.
[9]	Hokimoto S，Akasaka T，Tabata N，et al.Impact of Esomeprazole on platelet reactivity and clinical outcome according to CYP2C19 genotype in coronary heart disease patients during dual antiplatelet therapy[J].Thromb Res，2015，135（6）：1081-1086.
[10]	Ciccone MM，Iacoviello M，Puzzovivo A，et al.Clinical correlates of endothelial function in chronic heart failure[J].Clin Res Cardiol，2011，100（6）：515-521.
[11]	Yin Y，Xin X，Geng T，et al.Clinical comparison of percutaneous coronary intervention with domestic drug-eluting stents versus off pump coronary artery bypass grafting in unprotected left main coronary artery disease[J].Int J Clin Exp Med，2015，8（8）：14376.
[12]	Xiang W，Zhang J，Liu M，et al.Antithrombotic therapy in elderly patients with non-valvular atrial fibrillation：a pilot study[J].Clin Interv In Aging，2015，10（7）：14.
[13]	Shantsila E，Wrigley BJ，Blann AD，et al.A contemporary view on endothelial function in heart failure[J].Eur J Heart Fail，2012，14（8）：873-881.
[14]	Masson S，Latini R，Anand IS，et al.The prognostic value of big Endothelin-1 in more than 2300 patients with heart failure enrolled in the Valsartan Heart Failure Trial[J].J Card Fail，2016，22（5）：375-380.
[15]	Di Napoli P，Chierchia S，Taccardi AA，et al.Trimetazidine improves post-ischemic recovery by preserving endothelial nitric oxide synthase expression in isolated working rat hearts[J].Nitric Oxide，2007，16（2）：228-236.