大鼠肺缺血再灌注损伤中阿米洛利的作用机制分析

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Abstract Objective To explore the mechanism of effects of Amiloride on rats with pulmonary ischemia reperfusion injury.MethodsSeventy-two experimental male rats were selected and randomly divided into the IR group (the ischemia reperfusion group),the sham operation group(group C)and the Amiloride group(group A),24 rats in each group.After 45 min ischemia,60 min reperfusion and 120 min,rats in each group were anesthetized and killed,then plasma and right lung tissues were taken and detected.Results At 60 and 120 min reperfusion,malondialdehyde(MDA),apoptosis index(AI)in the IR group were significantly higher than those in the sham operation group.The Amiloride group was given drugs,MDA and AI were significantly lower,compared with the IR group(P＜0.05).Compared with the sham operation group,the lung wet/dry weight ratio(W/D)and myeloperoxidase(MPO)activity in the IR group at each time point were significantly increased(P＜0.05),while Amiloride after administration,the W/D in lung tissue and MPO activity decreased significantly.ConclusionAmiloride on lung ischemia reperfusion injury has a strong protective effect,this may be by reducing calcium ion,so as to remove the body of excess oxygen free radicals and inhibition of neutrophil infiltration and reduce cell apoptosis of purpose.

Key words： Lung ischemia-reperfusion injury Amiloride Oxygen free radicals

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	LIU Wei-cun

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LIU Wei-cun. Analysis on mechanism of effects of Amiloride on rats with pulmonary ischemia reperfusion injury[J]. 中国当代医药, 2018, 25(8): 21-23.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2018/V25/I8/21

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