辛伐他汀预防激素性股骨头坏死的实验研究

Abstract
Figure/Table
References (20)
Related Citation (11)

Download: PDF (0 KB) HTML (47 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the prevention effects of simvastatin against steroid-induced femoral head necrosis and to discuss its mechanism. Methods 36 New Zealand white rabbits were randomly divided into three groups,each with 12 rabbits.Rabbits in group A were intramuscularly injected by dexamethasone 2.5 mg/（kg·d）,rabbits in group B were orally given simvastatin 20 mg/d plus intramuscularly injected by dexamethasone 2.5 mg/（kg·d）,and rabbits in group C were orally given simvastatin 20 mg/d.The change of blood lipid was detected at the 12thweeks and histological observation of femoral head was conducted at the 12thweeks when the rabbits were executed. Results Compared with group B and group C,the differences of serum cholesterol,triacylglycerol,and NO level of rabbits in group A was statistically significant respectively（P＜0.05）.There was no significant difference between group B and group C（P＞0.05）.As to the level of bone metabolic markers including NO,osteocalcin（OCN）,and tartrate resistant acid phosphatase（TRAP-5b）, there was statistically significant difference between group A and group B（P＜0.01）,and between group A and group C （P＜0.01）, but no significant difference between group B and group C（P＞0.05）.Histological observation showed osteonecrosis and trabecular destruction in group A,which was not observed in group B or group C. Conclusion Simvastatin can regulate the lipid and bone metabolism,lower the blood lipid,inhibit the destruction of bone cells,and prevent femoral head necrosis.

Key words： Simvastatin Femoral head necrosis Steroid-induced

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Hui
	YIN Li
	ZHANG Yan-ru
	Kaka AA Katiella
	HAN Qi-cai

Cite this article:

ZHANG Hui,YIN Li,ZHANG Yan-ru, et al. Experimental study on simvastatin in prevention of steroid -induced femoral head necrosis[J]. 中国当代医药, 2016, 23(2): 11-13转17.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I2/11

[1]	郭先礼，李锋，方忠.辛伐他汀对早期激素性股骨头坏死的预防作用[J].华中科技大学学报（医学版），2006，35 （3）：346-349.
[2]	Hofbauer LC，Gori F，Riggs BL，et al.Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells：potential paracrine mechanisms of glucocorticoid -induced osteoporosis[J].Endocrinology，1999，140（10）：4382-4389.
[3]	李玉军，刘尚礼，卢世璧.一氧化氮对股骨头微循环的作用[J].中华骨科杂志，2000，20（4）：239-246.
[4]	李小川，付勤，贾长青，等.一氧化氮合酶抑制剂对延缓腰椎间盘退变的影响[J].中华实验外科杂志，2005，22（4）：479-481.
[5]	程少华，催超，常巍，等.激素性股骨头缺血性坏死细胞凋亡的实验研究[J].中华实用与治疗杂志，2010，24（4）：368-378.
[6]	王春生，王坤正，武永刚，等.激素性股骨头坏死血管病理的动物实验研究[J].中华关节外科杂志，2008，2（1）：29-35.
[7]	赵伦华，程少华，汤显斌，等.兔激素性股骨头缺血性坏死血管变化及对关节软骨的影响[J].陕西医学杂志，2008，37（3）：276-277.
[8]	Serafini M，Verfaillie CM.Pluripotency in adult stem cells：state of the art[J].Semin Reprod Med，2006，4（5）：379-388.
[9]	王少华，王义生，李月白.siRNA腺病毒载体预防兔酒精性股骨头坏死的动物实验研究[J].中国骨与关节外科，2010，3（1）：62-67.
[10]	Norman D，Misselevich I，Peled E，et al.Intraosseous conduit-induced enhancement of in growth of blood vessels into the necrotic femoral head of rats[J].J Orthop Trauma，2004，（5）：26-33.
[11]	孙伟，李子荣，史振才，等.纳米晶胶原基骨和骨髓间充质干细胞复合修复兔股骨头坏死缺损的研究[J].中国修复重建外科杂志，2005，19（9）：703-706.
[12]	石少辉，李子荣，孙伟，等.酒精性和激素性股骨头坏死的发病与脂质代谢[J].中国组织工程研究与临床康复，2011，15（17）：3217-3220.
[13]	Wang Y，Yin L，Li Y，et al.Preventive pucrarin onalcoholinduced ostconecrosis[J].Clin Orthop Rclat Rcs，2008，66（5）：1059-1067.
[14]	王维军，李嗣生，牛东生，等.股骨头缺血性坏死骨质含量与VEGF，bFGF，BMP-2 mRNA表达的相关性研究[J].中国修复重建外科杂志，2011，25（8）：984-991.
[15]	Hui JH，Buhary KS，Chowdhary A.Implantation of orthobiologic，biodegradable scaffolds in osteochondral repair[J]. Orthop Clin North Am，2012，43（2）：255-261.
[16]	张雁儒，张辉，马辉，等.BMP-2基因转染对兔骨髓间充质干细胞碱性磷酸酶活性和钙含量的影响[J]郑州大学学报（医学版），2014，49（1）：102-105.
[17]	Kang P，Shen B，Yang J，et al.Repairing defect and preventing collapse of canine femoral head using titanium implant enhanced by autogenous bone graft and rhBMP-2[J].Connective Tissue Res，2007，48（4）：171-179.
[18]	Pei M，Shoukry M，Li J，et al.Modulation of in vitro microenvironment facilitates synovium-derived stem cellbased nucleus pulposus tissue regeneration[J].Spine（Phila Pa 1976），2012，37（18）：1538-1547.
[19]	Park SH，Gil ES，Cho H，et al.Intervertebral disk tissue engineering using biphasic silk composite scaffolds [J]. Tissue Eng Part A，2012，18（5-6）：447-458.
[20]	Kim DW，Lee CM，Kim NH，et al.Radiolabeled chitosan hydrogel containing VEGF enhances angiogenesis in a rodent model of acute myocardial infarction[J].Macromol Res，2014，22（3）：272-278.