亚临床甲状腺功能异常患者血脂、血糖水平的变化及相关影响因素分析

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Abstract Objective To explore the change and affecting factors of blood lipid and glucose level in patients with subclinical thyroid dysfunction.Methods 300 subclinical thyroid dysfunctional patients with TSH＜0.350 mU/L received by our hospital were set as subclinical hyperthyroidism group，75 cases with TSH＞5.500 mU/L were set as subclinical hypothyroidism group，and 300 healthy examined persons were set as healthy control group from July 2011 to June 2015，then t test was used to compare the LDL，HDL，TG，TC，and GLU level between subclinical hyperthyroidism group，subclinical hypothyroidism group and healthy control group，while Pearson analysis method was used to detect the relationship between these indictors with TSH，T4，T3，FT4，and FT3，and Logistics regression was used to analyze the affecting factors for blood lipid and glucose level.Results Compared with healthy control group，HDL level in subclinical hyperthyroidism group was significantly rised (t=2.119，P=0.034)，and TC level in subclinical hypothyroidism group was significantly rised (t=2.036，P=0.042).In subclinical hyperthyroidism group，FT3level was positively correlated with HDL level (r= 0.107，P=0.009)，while in subclinical hypothyroidism group，T4level was negatively correlated with GLU level (r=-0.104，P=0.044)，FT3level was positively correlated with HDL level (r=0.105，P=0.042)，but negatively correlated with GLU level (r=-0.113，P=0.028).Smoking history was the risk factor for abnormal TG level in patients with subclinical thyroid dysfunction (P=0.023，OR=1.547，95%CI:0.740-1.806).Conclusion Blood lipid level is abnormal in patients with subclinical thyroid dysfunction，and it is related to partly indictors of thyroid function，and smoking is a risk factor in patients with dyslipidemia.

Key words： Subclinical hyperthyroidism Subclinical hypothyroidism Blood lipid Blood sugar

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CHEN Si-mei. The change and affecting factors of blood lipid and glucose level in patients with subclinical thyroid dysfunction[J]. 中国当代医药, 2016, 23(3): 111-114.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I3/111

[1]	戴自英.实用内科学[M].北京：人民卫生出版社，1994.
[2]	吴亚晓.甲状腺功能异常患者与血清糖，脂肪，蛋白质水平的相关性分析[J].放射免疫学杂志，2000，13（2）：100.
[3]	Surks MI，Ortiz E，Daniels GH，et al.Subclinical thyroid disease：scientific review and guidelines for diagnosis and management[J].JAMA，2004，291（2）：228-238.
[4]	Gharib H，Tuttle RM，Baskin HJ，et al.Subclinical thyroid dysfunction：a joint statement on management from the American Association of Clinical Endocrinologists，the American Thyroid Association，and the Endocrine Society [J].Thyroid，2005，15（1）：24-28.
[5]	Evans RM.The steroid and thyroid hormone receptor superfamily[J].Science，1988，240（4854）：889-895.
[6]	Anagnostis P，Efstathiadou ZA，Slavakis A，et al.The effect of L-thyroxine substitution on lipid profile，glucose homeostasis，inflammation and coagulation in patients with subclinical hypothyroidism[J].Int J Clin Pract，2014，68（7）：857-863.
[7]	Oetting A，Yen PM.New insights into thyroid hormone action[J].Best Pract Res Clin Endocrinol Metab，2007，21 （2）：193-208.
[8]	桑伟，田亮，郭长军，等.甲状腺癌患者血清促甲状腺激素和甲状腺激素表达水平及临床意义[J].现代生物医学进展，2010，10（4）：715-717.
[9]	邓顺有，陈广原，张彤.亚临床甲状腺功能减退症患者血脂，血糖和血尿酸变化分析[J].现代中西医结合杂志，2008，17（6）：816-817.
[10]	马德佳，李燕妮，何新发.亚临床甲状腺功能减退症患者血脂，血糖含量的变化分析[J].国际检验医学杂志，2011，32（21）：2534-2536.
[11]	梁利波，张玫，黄亨建，等.体检人群中亚临床甲状腺功能减退症患者血脂，血糖和血尿酸水平分析[J].四川大学学报（医学版），2013，44（6）：954-956.
[12]	张大鹏.甲状腺机能亢进和甲状腺功能减退症患者的血糖及血脂代谢异常[J].医药论坛杂志，2010，31（8）：54-55.
[13]	Tagami T，Tamanaha T，Shimazu S，et al.Lipid profiles in the untreated patients with Hashimoto thyroiditis and the effects of thyroxine treatment on subclinical hypothyroidism with Hashimoto thyroiditis[J].Endocr J，2010，57 （3）：253-258.
[14]	李光，刘向军，石铁跃，等.女性吸烟与血脂异常多因素分析[J].中国预防医学杂志，2009，10（4）：241-244.
[15]	Latha MS，Vijayammal PL，Kurup PA.Effect of exposure of rats to cigarette smoke on the metabolism of lipids[J].Atherosclerosis，1988，70（3）：225-231.