大鼠脑挫裂伤合并硬膜下血肿中TNF-α 及IL-1β的表达研究

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Abstract Objective To explore the expression of TNF-α and IL-1β in cerebral contusion and laceration complicated with subdural hematoma in rats.Methods One hundred and twenty rats were evenly divided into normal group and model group in random.The cerebral contusion and laceration complicated with subdural hematoma model was established by rapid decompression after injecting water using sacculus.Brain tissue was taken by craniotomy at 6 h，12 h and 24 h in model group.The expression of TNF-α and IL-1β in brain tissue were detected by SP immunohistochemistry.Results The TNF-α and IL-1β expression level in brain tissue at 6 h，12 h and 24 h in model group was greatly improved respectively，while the corresponding expression level in normal group was obviously decreased respectively，and there was a statistical difference between two groups (P＜0.05).Conclusion In the model of cerebral contusion and laceration complicated with subdural hematoma，expression level of TNF-α and IL-1β is greatly increase after 6 h，12 h and 24 h trauma，and it indicates that cerebral injury or edema.

Key words： Subdural hematoma；Cerebral trauma；TNF-&alpha ；IL-1&beta

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	HUANG Min-dong
	ZOU Jian-dan

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HUANG Min-dong,ZOU Jian-dan. Research of TNF-α and IL-1β expression in cerebral contusion and laceration complicated with subdural hematoma in rats[J]. 中国当代医药, 2016, 23(3): 105-107转110.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I3/105

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