间质性肺疾病患者呼出气冷凝液中8-异前列腺素及白三烯B4的水平及临床意义

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Abstract Objective To investigate the levels of 8-isoprostane(8-iso-PG) and leukotriene B4(LTB4) in exhaled breath condensate(EBC)and its clinical significance in interstitial lung disease(ILD).Methods 20 ILD patients in our department from August 2012 to December 2013 were selected as the ILD group，20 healthy subjects matched with age and body mass index were selected as control group.The levels of 8-iso-PG and LTB4 in EBC were measured by ELISA.Results The level of 8-iso-PG in ILD group was (9.69+2.8) ng/L，which was higher than that in control group(4.86+1.9) ng/L，with significant difference (P＜0.05).The level of LTB4 in EBC of ILD group was (15.46+6.6) ng/L，higher than that in control group (8.55+4.4) ng/L，the difference was statistically significant(P＜0.01).The specificity of LTB4 and 8-iso-PG was 85% respectively，and the sensitivity was 90% and 60% respectively.Conclusion 8-iso-PG and LTB4 increases in EBC of ILD patients.Measuring biomarkers in EBC may be useful to evaluate inflammatory response of ILD.

Key words： Interstitial lung disease Exhaled breath condensate 8-isoprostane Leukotriene B4

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	Articles by authors
	HUANG Li-xia
	LI Xiao-li
	HUANG Xiao-xing
	WU Cui-hua
	HONG Yong-zhong
	ZHONG Chun
	ZHU Yi-xin

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HUANG Li-xia,LI Xiao-li,HUANG Xiao-xing, et al. Levels of 8-isoprostane and leukotriene B4 in exhaled breath condensate and its clinical significance in interstitial lung disease[J]. 中国当代医药, 2016, 23(3): 34-36.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I3/34

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