大容量肺灌洗对肺尘埃沉着病患者T淋巴细胞亚群的影响及意义

Abstract
Figure/Table
References (13)
Related Citation (10)

Download: PDF (0 KB) HTML (42 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the effects and significance of large volume lung lavage on CD3+，CD4+and CD8+T lymphocytes in the peripheral blood in patients with pneumoconiosis.Methods 50 patients with pneumoconiosis who were hospitalized in our hospital from May 2014 to September 2015 and given large volume lung lavage were randomly collected.30 healthy males undergone physical examination in the community clinic in our hospital at the same period of time were also collected.The expression level of CD3+，CD4+and CD8+T lymphocytes in the peripheral blood in patients with pneumoconiosis before lung lavage and 1 week after lung lavage was tested.The expression level of CD3+，CD4+and CD8+T lymphocytes in the peripheral blood in healthy males was also tested.Their expression levels were compared and the comparison results were analyzed.Results Compared with the healthy control group，CD3+，CD4+，CD8+T lymphocytes，and CD4+/CD8+ratio in the peripheral blood in patients with pneumoconiosis was reduced respectively (P＜0.05)；After 1 week of large volume lung lavage，CD3+，CD4+T lymphocytes，and CD4+/CD8+ratio was increased respectively(P＜0.05)，and CD8+T was reduced(P＜0.05).Conclusion The cellular immune function in patients with pneumoconiosis is reduced，and large volume lung lavage is able to increase CD3+，CD4+T lymphocytes，and CD4+/CD8+ratio and reduce CD8+T lymphocytes for patients with pneumoconiosis，so as to improve the cellular immune function of patients with pneumoconiosis.

Key words： Pneumoconiosis Lung lavage T lymphocyte subgroup

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WAN Yin
	XU Man-qing
	ZHANG Ai-mei

Cite this article:

WAN Yin,XU Man-qing,ZHANG Ai-mei. Effect and significance of large volume lung lavage on T lymphocyte subgroup in patients with pneumoconiosis[J]. 中国当代医药, 2016, 23(3): 22-24.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I3/22

[5]	张映铭，王伟，王彩英，等.重复全肺灌洗术治疗矽肺的远期疗效[J].中华劳动卫生职业病杂志，2013，31（9）：681-684.
[6]	李艳军，陈刚.尘肺患者外周血T淋巴细胞亚群的改变[J].中华劳动卫生职业病杂志，2007，25（1）：50.
[7]	冯续有，王瑞.尘肺病人T细胞亚群的改变及其与肺功能的相关性研究[J].中国医疗前沿，2009，4（19）：3-6.
[8]	丁秀荣，石俊，李晓军，等.煤工尘肺患者γ-干扰素和淋巴细胞变化及意义[J].中国工业医学杂志，2006，19（5）：307-308.
[9]	卞陆琴，周彩存，施瑾，等.细胞因子和T细胞亚群与尘肺分期的相关性研究[J].中华劳动卫生职业病杂志，2012，30（4）：255-257.
[1]	Selecky PA，Wasserman K，Benfield JR，et al.The clinical and physiological effect of whole -lung lavage in pulmonary alveolar proteinosis: a ten-year experience[J].Ann Thorac Surg，1977，24（5）：451-461.
[2]	袁杨，刘贺.大容量灌洗尘肺患者全齐生存质量的评价[J].中华劳动卫生职业病杂志，2009，27（8）：483-484.
[3]	陈志远，张志浩，车审言，等.大容量全肺灌洗术医疗护理常规及操作规程[M].北京：北京科学技术出版社，2004：4-9.
[4]	戴伟荣.矽肺肺灌洗治疗对肺功能的影响分析[J].实用预防医学，2001，18（6）：1099-1100.
[10]	孙曙舫，胡颖颖，徐成伟.矽肺病人外周血T淋巴细胞亚群变化[J].中国工业医学杂志，2000，13（5）：303-304.
[11]	杨琳红，王瑁，孔令敏，等.尘肺患者T细胞亚群的改变与肺功能的关系[J].山东医药，2009，49（49）：86-87.
[12]	Peterson BT，Idell S，MacArthur C，et al.A modified bronchoalveolar lavage procedure that allows measurement of lung epithelial lining fluid volume[J].Am Rev Respir Dis，1990，141（2）：314-320.
[13]	谈万联，夏开屏.矽肺动物模型全肺灌洗治疗的病理观察[J].中华劳动卫生职业病杂志，1997，15（1）：22-24.