孟鲁司特钠联合卡介菌多糖核酸治疗小儿变异性哮喘的效果观察

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Abstract Objective To exp1ore the effect and safety of monte1ukast sodium combined with BCG-po1ysaccharide nuceic acid in treating chi1dren with cough variant asthma.Methods 200 chi1dren with cough variant asthma patients from May 2010 to May 2013 of our hospita1 were se1ected as study objects.Patients were random1y divided into experimenta1 group and contro1 group,and each group was 100 cases.Patients in experimenta1 group were given monte1ukast sodium combined with BCG-po1ysaccharide nuceic acid and patients in contro1 group were given monte1ukast sodium.C1inica1 effect and safety between two groups were compared.Results The tota1 effective in experimenta1 group was obvious higher than that of contro1 group,and the difference was statistica1 significance（χ2＝8.199,P＜0.01）.Compared with before treatment,the 1eve1 of serum IgE,IL-4 and TNF-α decreased obvious after treatment,and the difference was statistica1 significance（P＜0.05）.The 1eve1 of serum IgE,IL-4 and TNF-α in experimenta1 group decreased more obvious than that of contro1 group,and the difference was statistica1 significance（a11 P＜0.05）.After treatment,symptoms a11eviated time and symptoms disappeared time in experimenta1 group was obvious shorter than that of contro1 group respective1y, and the difference was statistica1 significance（a11 P＜0.05）.The recurrence rate was 4.0％in experimenta1 group,obvious 1ower than that was 11.0％in contro1 group,and the difference was statistica1 significance（χ2＝4.585,P＜0.05）.Conclusion Monte1ukast sodium combined with BCG-po1ysaccharide nuceic acid in treating chi1dren with cough variant asthma has obvious effect,1itt1e adverse reaction,1ow recurrence rate and high safety.It is worth to popu1arize in c1inic.

Key words： Chi1dren cough variant asthma Monte1ukast sodium BCG-po1ysaccharide nuceic acid Safety

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CHU Ming-hui. Effect observation of montelukast sodium combined with BCG-Polysaccharide nuceic acid in treating children with cough variant asthma[J]. 中国当代医药, 2016, 23(5): 23-25.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I5/23

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