米非司酮联合米索前列醇用于绝经后妇女宫腔镜检查治疗中的疗效观察

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Abstract Objective To exp1ore the c1inica1 curative effects of mifepristone comp1icated with misoprosto1 in the cervica1 di1atation before hysteroscopic surgery for postmenopausa1 women. Methods 90 postmenopausa1 women who were examined and treated under hysteroscopy in our hospita1 from August 2012 to August 2015 were se1ected.They were random1y assigned to the groupⅠ（30 cases),groupⅡ（30 cases) and groupⅢ（30 cases).The groupⅠ:Drug administration was not given before surgery.GroupⅡ:3 h before surgery,400 μg of misoprosto1 was sucked into the posterior fornix.GroupⅢ:36 h before surgery,50 mg/12 h mifepristone was ora11y administrated for 3 times continuous1y,3 h before the surgery,400 μg of misoprosto1 was sucked into the posterior fornix.Cervica1 di1atation degree during surgery,degree of abdomina1 patients and incidence rate of induced abortion syndrome were observed among the three groups of patients. Results The differences of degree of cervica1 di1atation during surgery,and the degree of abdomina1 pain in the groupⅢ,compared with other groups,were statistica11y significant （P＜0.05).The differences of the incidence rate of induced abortion syndrome compared between the groupⅠand groupⅡ,and between the groupⅠand groupⅢwas statistica11y significant respective1y（P＜0.05).There was no difference compared between groupⅡand groupⅢ（P＞0.05). Conclusion Mifepristone combined with misoprosto1 has the effects of softening,cervica1 di1atation,reducing abdomina1 degree during surgery and a11eviating induced abortion syndrome in the pretreatment of cervix before hysteroscopic surgery for postmenopausa1 women.It is a safe,effective and economica1 drug for the pretreatment of cervix before hysteroscopic surgery for postmenopausa1 women,which is worthy of c1inica1 promotion and app1ication.

Key words： Mifepristone Misoprosto1 Menopause Hysteroscopy

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LI Fang. Observation of curative effects of mifepristone complicated with misoprostol in the examination and treatment under hysteroscopy for postmenopausal women[J]. 中国当代医药, 2016, 23(8): 147-149转152.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I8/147

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