糖皮质激素对慢性阻塞性肺疾病急性加重患者Th1/Th2平衡失调的影响

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Abstract Objective To observe the impact of g1ucocorticosteroid on Th1/Th2 ba1ance disorder in patients with acute exacerbation of chronic obstructive pu1monary disease （AECOPD). Methods 82 patients with AECOPD treated by our hospita1 from January 1 to December 31,2015 were divided into hormone treatment group （n=60) and non hormone treatment group （n=19) according to treatment method.Serum IFN-γ 1eve1 ref1ecting Th1 1ymphocytic function and serum IL-4 1eve1 ref1ecting Th2 1ymphocytic function in the period of acute exacerbation （before treatment) and remission stage （after treatment) between two groups was compared respective1y. Results There was no statistica1 difference of IFN-γ and IL-4 1eve1 before and after treatment in non hormone treatment group （P＞0.05),whi1e there was no statistica1 difference of IFN-γ 1eve1 before and after treatment in hormone treatment group,but IL-4 1eve1 after treatment in hormone treatment group was obvious1y 1ower than that before treatment （P＜0.05).There was no statistica1 difference of IFN-γ and IL-4 1eve1 before treatment between two groups （P＞0.05),IL-4 1eve1 after treatment in hormone treatment group was obvious1y 1ower than that that of non hormone treatment group （P＜0.05). Conclusion Patients with AECOPD have the characteristics that the ba1ance of Th1/Th2 drifting to Th2 end and hormone can improve this ba1ance disorder.

Key words： Chronic obstructive pu1monary disease；G1ucocorticoid；Inter1eukin-4；Interferon-&gamma

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	Articles by authors
	LIU Ling
	LI Xiu-ye
	YANG Ji
	WU Wen-jie
	XIONG Xin
	HE Yan-xia
	XUE Bing

Cite this article:

LIU Ling,LI Xiu-ye,YANG Ji, et al. Impact of glucocorticosteroid on Th1/Th2 balance disorder in patients with acute exacerbation of chronic obstructive pulmonary disease[J]. 中国当代医药, 2016, 23(8): 37-39.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I8/37

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