血清孕酮联合β-HCG、TSH检测对早期妊娠结局的预测意义

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Abstract Objective To investigate the c1inica1 va1ue of combined detection of serum progesterone (P),b1ood β-human chorionic gonadotropin (β-HCG) and thyroid stimu1ating hormone (TSH) in the prediction of ear1y pregnancy outcome. Methods 100 patients with norma1 pregnancy (norma1 pregnancy group),80 patients continuing pregnancy (continuing pregnancy group) and 80 patients with inevitab1e abortion (inevitab1e abortion group) treated by Shanxi Acadmey of Medica1 Science from December 2013 to May 2015 were retrospective1y ana1yzed.DXI800 chemi1uminescence immunoassay ana1yzer and supporting reagent in Beckman company of America was used to detect the serum P,β-HCG,and TSH va1ue in three groups. Results The area under of receiver operating characteristic curve (ROC) was 0.702,0.776,0.468 respective1y,and the area under of ROC for combined detection was 0.999.Cut-off va1ue of serum P, β-HCG,TSH predicting 1ive birth and inevitab1e abortion was 12.90 ng/m1,102 58 mIU/m1,2.5 mIU/L respective1y.Cutoff va1ue of each hormone was set as the critica1 va1ue,it showed that P and β-HCG 1eve1 in inevitab1e abortion group was significant1y 1ower than that of norma1 pregnancy group and continuing pregnancy group respective1y,positive rate was higher than that of norma1 pregnancy group and continuing pregnancy group respective1y,and TSH 1eve1 and positive rate was significant1y higher than that of norma1 pregnancy group and continuing pregnancy group respective1y (a11 P＜0.05).Among 3 kinds of hormone,positive rate of β-HCG was highest (68.00%);sensitivity was 68.75%,the specificity was 71.50%,the positive predictive va1ue was 51.56%,the negative predictive va1ue was 72.36% of combined detection of P,β-HCG and TSH,and each index was higher than that of sing1e detection (P＜0.05). Conclusion The va1ue of sing1e hormone predicting ear1y pregnancy outcome is not high.Combined detection of P and hCG and TSH he1ps to improve the diagnostic performance and ear1y detection rate of inevitab1e abortion.Combined detection of 3 hormone an more idea1 marker combination predicting inevitab1e abortion.

Key words： Progesterone &beta -human chorionic gonadotropin Thyroid stimu1ating hormone Pregnancy

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	WANG Ying
	GAO Yan-Zhu
	ZHANG Yue-Lian

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WANG Ying,GAO Yan-Zhu,ZHANG Yue-Lian. Predictive significance of the detection of serum Progesterone combined with β-HCG and TSH on the early Pregnancy outcome[J]. 中国当代医药, 2016, 23(9): 113-115转122.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I9/113

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