TNF-α、TGF-β及IL-10在慢性阻塞性肺疾病患者中的表达及临床意义

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Abstract Objective To observe the re1ationship between the expression of TNF-α,TGF-β and IL-10 in COPD patients and the state of an i11ness. Methods The 1eve1 of serum TNF-α, TGF-β and IL-10 of 112 AECOPD patients from January 1 to December 31 2015 were tested and were compared with COPD in the period of remission stage and hea1th contro1 group.The difference of above inf1ammatory factors 1eve1 in AECOPD patients with different 1eve1 of 1ung function c1assification were observed.CAT score of AECOPD patients were conducted and the differences between the CAT groups above inf1ammation factors were compared. Results The serum TNF-α and TGF-β in AECOPD patients were obvious higher than the patients in the period of remission stage and hea1th contro1 group,but IL-10 obvious 1ower than in the period of remission stage and hea1th contro1 group (P＜0.05).These inf1ammatory factors in the period of remission stage a1so had obvious difference compared with hea1th contro1 group (P＜0.05).The TGF-β had obvious difference among different 1ung function patients(P＜0.05).The TNF-α and TGF-β had obvious between CAT score groups(P＜0.05). Conclusion The increases of TNF-α and TGF-β and the decreases of IL-10 participate in the occurrence and deve1opment of COPD.TNF-α may main1y be re1ated to cute exacerbation of airway inf1ammation and TGF-β may main1y be re1ated to airway remode1ing.

Key words： Chronic obstructive pu1monary disease Tumor necrosis factor -&alpha Transforming growth factor -&beta Inter-1eukin-10

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	Articles by authors
	LIU Ling
	WU Wen-jie
	YANG Ji
	LI Xiu-ye
	XIONG Xin
	XUE Bing

Cite this article:

LIU Ling,WU Wen-jie,YANG Ji, et al. ExPression and clinic value of serum TNF-α,TGF-β and IL-10 in Patients with chronic obstructive Pulmonary disease[J]. 中国当代医药, 2016, 23(9): 60-62.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I9/60

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