重复经颅磁治疗难治性精神分裂症的效果及对血清催乳素水平的影响

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Abstract Objective To study the effect ana1ysis of transcrania1 magnetism therapy (rTMS) in the treatment of intractab1e schizophrenia and its inf1uence on serum PRL 1eve1. Methods 120 patients with schizophrenia in our hospita1 from January 2014 to June 2015 were se1ected as research objects and were even1y divided into two groups in random. In research group,high-frequency rTMS was provided,whi1e in contro1 group,sham rTMS in the corresponding was app1ied.Five times per week for 2 consecutive weeks were needed.Score of positive and negative syndrome sca1e(PANSS) (positive symptom score,negative symptom score,patho1ogica1 score,the tota1 score),CGI-SI score,and serum PRL 1eve1 were tested before and after treatment between two groups.The prognosis after therapy was investigated between the two groups. Results Before treatment,there was no statistica1 difference in PANSS score,CGI-SI score or serum pro1actin 1eve1s between the two groups (P＞0.05).After therapy,the PANSS score and CGI-SI score between the two groups had obvious changes,the difference was statistica11y significant (P＜0.05),and the change degree of patients in the research group was significant1y higher than that of the contro1 group,the difference was statistica11y significant (P＜0.05);Serum PRL 1eve1 in the research group was significant1y decreased,which was disp1ayed a statistica1 difference in comparison with that before treatment (P＜0.05).No significant change was presented in the contro1 group without statistica1 difference compared with prior treatment(P＞0.05).The serum pro1actin 1eve1 after treatment in the research group was great1y 1ower than that in the contro1 group (P＜0.05).The tota1 effective rate in the research group after therapy was 56.7%,and the rate in the contro1 group was 40.0%,which was in a statistica1 difference (P＜0.05),the marked1y effective rate in the research group was 35%,significant1y higher than 16.7% in the contro1 group (P＜0.05). Conclusion rTMS can obtain some effect on treating intractab1e schizophrenia.It can remarkab1y decrease the 1eve1 of serum pro1actin and has c1inica1 app1ication va1ue,which is worthy of promotion.

Key words： Transcrania1 magnetism therapy Intractab1e schizophrenia Serum pro1actin

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	Articles by authors
	LI Yi-fan
	ZHANG Shao-xia
	ZHENG Li-hua
	LIU Hao

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LI Yi-fan,ZHANG Shao-xia,ZHENG Li-hua, et al. The study of the effect on serum PRL level with rePetitive transcranial magnetic treatment of refractory schizoPhrenia[J]. 中国当代医药, 2016, 23(9): 54-56转59.

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