马来酸依那普利叶酸片对MTHFR基因多态的H型高血压患者的疗效观察

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Abstract Objective To observe the effects of ena1apri1 ma1eate-fo1ate tab1et in H type hypertension patients with MTHFR gene po1ymorphism. Methods 480 H type hypertension patients from June 2011 to March 2014 of our hospita1 were se1ected and were divided into experimenta1 group that treated with ena1apri1 ma1eate-fo1ate tab1et and contro1 group that treated simp1y or combined with other CCB,drain potassium diuretics,ACEI or ARB.The index of systo1ic pressure,diasto1ic pressure,homocysteine and MTHFR gene in two groups before and after treatment were tested. Results Before treatment,the systo1ic pressure,diasto1ic pressure and Hcy with CC,CT and TT gene type between observation group and contro1 group had no statistica1 significance(P＞0.05).After treatment for 1,2 and 3 months,a11 of the systo1ic pressure,diasto1ic pressure and Hcy with CC,CT and TT gene type in observation group decreased obvious1y compared with before treatment,and the TT type decreased most,and the difference was statistica1 significance (P＜0.05).A-mong patients in observation group,the systo1ic pressure,diasto1ic pressure and Hcy with CC,CT and TT gene type were decreased when compared the treatment for 1 and 2 months or 2 and 3 months,and the difference was statistica1 significance(P＜0.05). Conclusion Ena1apri1 ma1eate-fo1ate tab1et can decrease Hcy better than using other hypotensive drugs, especia11y for TT gene type patients,which has obvious effects.

Key words： Ena1apri1 ma1eate-fo1ate tab1et Homocysteine MTHFR gene type

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	XIE Sheng

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XIE Sheng. Effects observation of enalaPril maleate-folate tablet in H tyPe hyPertension Patients with MTHFR gene PolymorPhism[J]. 中国当代医药, 2016, 23(9): 32-34转38.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I9/32

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