p38 MAPK与七氟醚心肌保护作用的关系研究进展

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Abstract As a vo1ati1e anesthetic,sevof1urane has been avai1ab1e for c1inica1 anesthesia in recent years,and it has been previous1y demonstrated that sevof1urane at the concentration of c1inica1 anesthesia exerts cardioprotective effect against myocardia1 injury.And the myocardia1 protection mechanism of sevof1urane may be corre1ation with a variety of intrace11u1ar signa1 transduction pathways,inc1uding protein kinase C (PKC),protein tyrosine kinase (PTK) and mitogenactivated protein kinase (MAPK) pathway.p38 MAPK,as an important MAPK signa1ing pathway,p1ays an important ro1e in ce11 pro1iferation and differentiation，apoptosis，metabo1ism and stress reaction,and has been another myocardia1 protection signa1 pathway.This review wi11 summarize the re1ationship between p38 MAPK and myocardia1 protection of sevof1urane.

Key words： p38 MAPK Sevof1urane Myocardia1 protection Research progress

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	Articles by authors
	WU Ting
	JIA Hao
	MA Qin
	ZHAO Jian-li

Cite this article:

WU Ting,JIA Hao,MA Qin, et al. Research Progress of the role of P38 MAPK in myocardial Protection of sevoflurane[J]. 中国当代医药, 2016, 23(9): 22-24.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I9/22

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