短期胰岛素泵强化治疗对新诊断2型糖尿病患者血糖控制及血管内皮功能的影响

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Abstract Objective To observe the influence of short-term insulin pump intensive treatment on blood glucose control and vascular endothelial function in newly diagnosed type 2 diabetic patients. Methods From January 2013 to December 2014，60 newly diagnosed type 2 diabetic patients treated in our hospital were evenly divided into observation group and control in random.In the observation group，continuous subcutaneous insulin pump infusion after being admitted into hospital was provided，while in the control group，subcutaneous injections of insulin for several times was adopted.They were treatmented two weeks.The fasting blood glucose（FBG），postprandial 2 h blood glucose（2 h PBG），fasting insulin（F-INS），fasting C-peptide（F-C peptide）and fructosamine（FA）before and after therapy were observed in both groups.Flow-mediated dilation（FMD）function of brachial artery was measured by high-frequency color Doppler. Results After therapy，FBG，2 h PBG，and FA in both groups were all decreased（P＜0.05）.In the observation group，the levels of F-INS and F-C peptide were increased to some extent compared with prior treatment and the increased levels were superior to those in the control group（P＜0.05）.In the observation group，the blood glucose reaching the standard was shorter than that of control group，dosage of insulin was fewer than that of control group，and incidence of hypoglycemia was lower than that of control group（P＜0.05）.There was no significant difference in FMD before treatment.After therapy，FMD in both groups was greatly improved，and improvement of FMD in the observation group was better than that of control group （P＜0.05）. Conclusion For newly diagnosed type 2 diabetic patients，application of insulin pump for short-term intensive treatment can control blood glucose safe and effective，and improve endothelial function，which has remarkable advantages in comparison with traditional subcutaneous injections of insulin for multiple times.

Key words： Newly diagnosed type 2 diabetics Insulin pump Endothelial function Blood glucose

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	ZHOU Yan-hua
	LIN Sen
	LIU Jie

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ZHOU Yan-hua,LIN Sen,LIU Jie. Influence of short-term insulin PumP intensive treatment on blood glucose control and vascular endothelial function in newly diagnosed tyPe 2 diabetic Patients[J]. 中国当代医药, 2016, 23(11): 32-35.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I11/32

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