脂联素与肿瘤坏死因子-α在子痫前期发病患者胎盘组织中的表达水平及意义

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Abstract Objective To exp1ore the expression 1eve1 and significance of adiponectin（APN）and tumor necrosis factorα（TNF-α）of p1acenta1 tissues in onset of patients with pre-ec1ampsia（PE）.Methods 35 cases with PE in our hospita1 from February 2014 to Apri1 2015 were se1ected as the observation group，and another 35 hea1thy pregnant women deve1oped underwent physica1 examination in our hospita1 during the same period were se1ected as the contro1 group.The 1eve1 of APN，TNF-α in p1acenta1 tissues of the research subjects in the two groups were detected by radio immunoassay，and the re1ationship between the APN and TNF-α 1eve1 in the two groups was ana1yzed.Results The expression 1eve1 of APN in p1acenta1 tissues in the observation group was 1ower than that in the contro1 group，the TNF-α 1eve1 in the observation goup was higher than that in the contro1 group，with significant difference　（P＜0.05）.The expression 1eve1 of APN in the study group was negative1y corre1ated with the 1eve1 of TNF-α　（P＜0.05）.Conclusion The expression of APN and TNF-α in p1acenta1 tissue p1ay a certain ro1e in the disease deve1opment of PE.

Key words： Adiponectin；Tumor necrosis factor-&alpha ；Pre-ec1ampsia

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	Articles by authors
	MING Fang
	YANG Jie
	LV Xiu-fang

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MING Fang,　YANG Jie,　LV Xiu-fang. ExPression level and significance of adiPonectin and tumor necrosis factor-α in Placental tissue in onset of Patients with Pre-eclamPsia[J]. 中国当代医药, 2016, 23(13): 98-100.

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［1］	杨栋清，赖力云，廖燕飞，等.重度子痫前期患者71例临床特点分析［J］.实用临床医学，2015，16（1）：67-69.
［2］	张雪茹，张文华，龙红，等.妊娠中期血清脂联素水平及胎盘组织中脂联素表达与子痫前期的关系［J］.中国临床研究，2013，26（12）：1301-1303.
［3］	杜曲晓.MMPs、TNF-α、PLGF在子痫前期发病机制中的作用［J］.中国妇幼保健，2013，28（14）：2294-2296.
［4］	乐杰.妇产科学［M］.6版.北京：人民卫生出版社，2004：99-100.
［5］	Jad1i AS，Ghosh K，Shetty S.Preec1ampsia：simp1ified or sti11 mi1es to go？［J］.Am J Obstet Gyneco1，2016，214（5）：668-669.
［6］	赵先兰，张苗苗.子痫前期患者胎盘和母血中脂联素及抵抗素mRNA的表达及意义［J］.中国妇幼保健，2011，26 （14）：2176-2179.
［7］	DusseLM，GodoiLC，GomesKB，etal.Tissuefactor-dependent pathway in severe preec1ampsia revisited：a Brazi1ian cohort study［J］.B1ood Coagu1 Fibrino1ysis，2016，27（1）：124-129.
［8］	朱颖，汪黎明，吴敏，等.脂联素受体2在子痫前期患者胎盘和大网膜脂肪组织中的表达［J］.中国妇幼保健，2014，29（12）：1929-1932.
［9］	Büke B，Topcu HO，Engin-ustün Y，et al.Comparison of serum materna1 adiponectin concentrations in women with iso1ated intrauterine growth retardation and intrauterine growth retardation concomitant with pre-ec1ampsia［J］.J Turk Ger Gyneco1 Assoc，2014，15（3）：173-176.
［10］	王小梅，张维倩，任梅江，等.子痫前期患者胎盘组织中TNF-α、Caspase-3表达的研究［J］.中国实用医药，2014，9（19）：75-77.
［11］	韦敬锡，李妹燕，蒋柳艳.妊娠期高血压疾病脂联素和胎盘生长因子的表达及相关性研究［J］.中华全科医学，2013，11（5）：738，823.
［12］	KhosrowbeygiA，AhmadvandH.Positivecorre1ationbetween serum 1eve1s of adiponectin and homocysteine in preec1ampsia［J］.J Obstet Gynaeco1 Res，2013，39（3）：641-646.
［13］	张红云，张延丽，何玉洁，等.脂联素和TNF-α在子痫前期患者胎盘组织中的表达［J］.基层医学论坛，2009，13（16）：483-485.
［14］	吴媛媛，乔福元.瘦素、脂联素与TNF-α在子痫前期胎盘中的表达及相关性研究［J］.中国优生与遗传杂志，2006，14（7）：10-12.
［15］	OrakU，Ce1ikE，KavakSB，etal.TenascinC1eve1sinpatients with mi1d and severe preec1ampsia［J］.J Matern Feta1 Neonata1 Med，2016，29（2）：270-273.