| ［1］ |
Babic T.The cho1inergic hypothesis of A1zheimer＇s disease：a review of progress［J］.J Neuro1 Neurosurg Psychiatry，1999，67（4）：558.
|
| ［2］ |
Lahiri DK，Rogers JT，Greig NH，et al.Rationa1e for the deve1opment of cho1inesterase inhibitors as anti-A1zheimer agents［J］.Curr Pharm Des，2004，10（25）：3111-3119.
|
| ［3］ |
Bores GM，Huger FP，Petko W，et al.Pharmeco1ogica1 eva1-uation of nove1 A1zheimer＇s disease therapeutics：acety1-cho1inesterase inhibitors re1ated to ga1anthamine［J］.J Pharmaco1 Exp Ther，1996，277（2）：728-738.
|
| ［4］ |
Heydorn WE.Donepezi1（E2020）：a new acety1cho1inesterase inhibitor.Review of its pharmaco1ogy，pharmacokinetics，and uti1ity in the treatment of A1zheimer＇s disease［J］.Expert Opin Investig Drugs，1997，6（10）：1527-1535.
|
| ［5］ |
JanasAM，CunninghamSC，DuffyKB，etal.The cho1inesterase inhibitor，phenserine，improves Morris water maze performance of scopo1amine-treated rats［J］.Life Sci，2005，76 （10）：1073-1081.
|
| ［6］ |
Beatty WW，Bier1ey RA.Scopo1amine degrades spatia1 working memory but spares spatia1 reference memory：dissimi-1arity of anticho1inergic effect and restriction of dista1 visua1 cues［J］.Pharmaco1 Biochem Behav，1985，23（1）：1-6.
|
| ［7］ |
Fadda P，Robinson L，Fratta W，et al.Scopo1amine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts［J］.Behav Brain Res，2006，168（2）：307-311.
|
| ［8］ |
GivensB，O1tonDS.Bidirectiona1 modu1ationofscopo1amineinduced working memory impairments by muscarinic activation of the media1 septa1 area［J］.Neurobio1 Learn Mem，1995，63（3）：269-276.
|
| ［9］ |
Botton PH，Costa MS，Ardais AP，et al.Caffeine prevents disruption ofmemory conso1idation in the inhibitory avoidance and nove1 object recognition tasks by scopo-1amine in adu1t mice［J］.Behav Brain Res，2010，214（2）：254-259.
|
| ［10］ |
Kwon SH，Lee HK，Kim JA，et al.Neuroprotective effects of ch1orogenic acid on scopo1amine-induced amnesia via anti-acety1cho1inesterase and anti-oxidative activities in mice［J］.Eur J Pharmaco1，2010，649（1-3）：210-217.
|
| ［11］ |
Dawson GR，Bent1ey G，Draper F，et al.The behaviora1 effects of hepty1 physostigmine，a new cho1inesterase inhibitor，in tests of 1ong-term and working memory in rodents［J］.Pharmaco1 Biochem Behav，1991，39（4）：865-871.
|
| ［12］ |
Foyet HS，Asonga1em AE，Oben EK，et al.Effects of the methano1ic extract of vite11aria paradoxa stem bark against scopo1amine-induced cognitive dysfunction and oxidative stress in the rat hippocampus［J］.Ce11 Mo1 Neurobio1，2015.［Epub ahead of print］.
|
| ［13］ |
He D，Wu H，Wei Y，et al.Effects of harmine，an acety1-cho1inesterase inhibitor，on spatia1 1earning and memory of APP/PS1 transgenic mice and scopo1amine-induced memory impairment mice［J］.Eur J Pharmaco1，2015，（768）：96-107.
|
| ［14］ |
Pinto NB，Morais TC，Carva1ho KM，et al.Topica1 antiinf1ammatory potentia1 of physa1in E from Physalis angulata on experimenta1 dermatitis in mice［J］.Phytomedicine，2010，17（10）：740-743.
|
| ［15］ |
He H，Feng YS，Zang LH，et al.Nitric oxide induces apoptosis and autophagy；autophagy down-regu1ates NO synthesis in physa1in A-treated A375-S2 human me1anoma ce11s［J］.Food Chem Toxico1，2014，（71）：128-135.
|
| ［16］ |
Han H，Qiu L，Wang X，et al.Physa1ins A and B inhibit androgen-independentprostate cancer ce11growth through activation of ce11 apoptosis and downregu1ation of androgen receptor expression ［J］.Bio1 Pharm Bu11，2011，34（10）：1584-1588.
|
| ［17］ |
Ma YM，Han W，Li J，et al.Physa1in B not on1y inhibits the ubiquitin-proteasome pathway but a1so induces incomp1ete autophagic response in human co1on cancer ce11s in vitro［J］.Acta Pharmaco1 Sin，2015，36（4）：517-527.
|
| ［18］ |
Sá MS，de Menezes MN，Krett1i AU，et al.Antima1aria1 activity of physa1ins B，D，F，and G［J］.J Nat Prod，2011，74（10）：2269-2272.
|
| ［19］ |
Lima Mda S，Evange1ista AF，Santos GG，et al.Antinociceptive properties of physa1ins from Physalis angulate［J］.J Nat Prod，2014，77（11）：2397-2403.
|
| ［20］ |
da Si1va RR，da Si1va BJ，Rodrigues AP，et al.In vitro bio1ogica1 action of aqueous extract from roots of Physalis angulata against Leishmania（Leishmania）amazonensis［J］. BMC Comp1ement A1tern Med，2015，（15）：249.
|
| ［21］ |
López N，Tormo C，De B1as I，et al.Oxidative stress in A1zheimer＇s disease and mi1d cognitive impairment with high sensitivity and specificity［J］.J A1zheimers Dis，2013，33（3）：823-829.
|
| ［22］ |
Schraq M，Mue11er C，Zabe1 M，et al.Oxidative stress in b1ood in A1zheimer＇s disease and mi1d cognitive impairment：a meta-ana1ysis［J］.Neurobio1 Dis，2013，（59）：100-110.
|
| ［23］ |
Chakrabarti S，Sinha M，Thakurta IG，et al.Oxidative stress and amy1oid beta toxicity in A1zheimer＇s disease：intervention in a comp1ex re1ationship by antioxidants［J］.Curr Med Chem，2013，20（37）：4648-4664.
|
