玻璃体腔注射雷珠单抗联合黄斑区格栅样光凝治疗视网膜分支静脉阻塞继发黄斑水肿的效果

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Abstract Objective To observe the effectiveness and safety of combined therapy of intravitreal ranibizumab with grid laser photocoagulation for macular edema secondary to branch retinal vein occlusion（BRVO）.Methods Thirty-two eyes of 32 patients with macular edema secondary to BRVO in People′s Hospital of Meizhou City from July 2014 to July 2015 were randomized into two groups：laser group　（16 eyes）were given grid laser photocoagulation and compound Xueshuantong capsule，combined group（16 eyes）were given a single dose of intravitreal ranibizumab（0.05 ml/0.5 mg）and followed by grid laser photocoagulation after 1 week，combined with compound Xueshuantongcapsule.Follow-up for 6 months，the changes of best-corrected visual acuity　（BCVA）checked bg early treatment diabetic retinopathy study（ETDRS）and central macular thickness（CMT）among before treatment and 1month，3，6 months after theatment were compared in the two groups，the ocular and systemic adverse reactions about treatments were also followed up.Results The BCVA before treatment in the laser group was　（21.8±8.63）letters，which was significantly improved to　（33.5±9.76）letters，（31.6±9.96）letters，（30.5±8.83）letters respectively，at 1 month，3，6 months after treatment（P＜0.05）.The BCVA before treatment in the combined group was　（21.4±9.12）letters，which was also significantly improved to　（40.4±10.01）letters，（39.8±9.91）letters，（39.6±9.24）letters respectively，at 1 month，3，6 months after treatment（P＜0.05）.The CMT before treatment in the laser group was　（549.2±120.4）μm，which was significantly reduced to（290.3±88.6），（268.9±78.5），（252.4±66.3）μm respectively，at 1 month，3，6 months after treatment（P＜0.05）.The CMT before treatment in the combined group was（550.6±114.8）μm，which was significantly reduced to　（206.2±54.7），（190.1±53.8），（180.5±34.6）μm respectively，at 1month，3，6 months after treatment（P＜0.05）.The BCVA was better and the CMT was thinner in the combined group than that in the laser group at 1 month，3，6 months after treatment respectively （P＜0.05）.No ocular or systemic adverse reactions was observed during follow-up period.Conclusion Intravitreal ranibizumab injection combined with grid laser photocoagulation，which can significantly improve vision and is a clinical effective and safe method for macular edema secondary to BRVO.The curative effect of combined treatment is better than that of grid laser photocoagulation alone.

Key words： Branch retinal vein occlusion Macular edema Ranibizumab Laser photocoagulation

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LAN Cheng-hong. Clinical observation of intravitreal ranibizumab injection combined with grid laser photocoagulation in the treatment of macular edema secondary to branch retinal vein occlusion[J]. 中国当代医药, 2016, 23(17): 119-122.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I17/119

［1］	Zhou JQ，Xu L，Wang S，et al.The 10-year incidence and risk factors of retinal vein occlusion：the Beijing eye study ［J］.Ophthalmology，2013，120（4）：803-808.
［2］	Esrick E，Subranian ML，Heier J，et al.Multiple laser treatments for macular edema attributable to branch retinal vein occlusion［J］.Am J 0phthalmol，2005，139（4）：653-657.
［3］	宋爽，喻晓兵，戴虹.玻璃体腔注射雷珠单抗联合曲安奈德或激光光凝治疗视网膜分支静脉阻塞继发黄斑水肿疗效观察［J］.中华眼底病杂志，2015，31（1）：18-21.
［4］	张聪，许贺，徐丽.玻璃体腔注射Ranibizumab联合激光治疗BRVO继发黄斑水肿的观察［J］.国际眼科杂志，2014，14（8）：1399-1402.
［5］	Noma H，Funatsu H，Yamasaki M，et al.Pathogenesis of macular edema with branch retinal vein occlusion and intraocular levels of vascular endothelial growth factor and interleukin-6［J］.Am J Ophthalmol，2005，140（2）：256-261.
［6］	Noma H，Funatsu H，Yamasaki M，et al.Aqueous humour levels of cytokines are correlated to vitreous levels and severity of macular oedema in branch retinal vein occlusion［J］.Eye，2008，22（1）：42-48.
［7］	Pece A，Isola V，Piermarocchi S，et al.Efficacy and safety of antivascular endothelial growth factor（VEGF）therapy with intravitreal ranibizumab for naive retinal vein occlusion：1-year follow-up［J］.Br J Ophthalmol，2011，95（1）：56-58.
［8］	Rouvas A，Petrou P，Ntouraki A，et al.Intravitreal ranibizumab for branch retinal vein occlusion-induced macular edema：nine-month results of a prospective study［J］.Retina，2010，30（6）：893-902.
［9］	Thach　AB，Yau　L，Hoang　C，etal.Time　to　clinically significant visual acuity gains after ranibizumab treatment for retina vein occlusion：BRVAVO and CRUISE trials［J］. Ophthalmology，2014，121（5）：1059-1066.
［10］	刘斌，杨玉霞，刘杏，等.玻璃体腔注射Ranibizumab联合视网膜光凝治疗视网膜分支静脉阻塞继发黄斑水肿［J］.国际眼科杂志，2014，14（11）：2006-2008.
［11］	Ohashi H，Oh H，Nishiwaki H，et al.Delayed absorption of macular edema accompanying serous retinal detachment after grid laser treatment in patients with branch retinal vein occlusion［J］.Ophthalmology，2004，111（11）：2050-2056.
［12］	孙晓东，宫媛媛，汪枫桦.慎重应用抗新生血管药物治疗视网膜静脉阻塞继发的黄斑水肿［J］.中华眼科杂志，2010，46（2）：100-102.
［13］	汪枫桦，张鹏飞，孙晓东.抗血管内皮生长因子治疗不应忽视激光的作用［J］.中华眼科杂志，2015，51（12）：885-887.
［14］	杨雪艳，何锦贤，梁先军，等.Lucentis联合黄斑区格栅样光凝治疗视网膜分支静脉阻塞黄斑水肿的临床观察［J］.临床眼科杂志，2015，23（1）：39.
［15］	杨瑞芳，杜红艳.雷珠单抗联合激光光凝治疗视网膜分支静脉阻塞继发黄斑水肿的疗效［J］.国际眼科杂志，2016，16（1）：103-106.