Objective To explore the effect of magnetic resonance guided argon helium targeted ablation combined with CIK biological therapy in treating liver metastasis from colon cancer.Methods 37 liver metastasis from colon cancer patients，accepted treatment in Jilin Provincial People′s Hospital from January 2010 to December 2012 were selected and were random divided into freeze ablation group　（n=15），CIK biological therapy group　（n=10）and freeze ablation combined with CIK biological therapy group　（n=12）according to the treatment method.The three groups were respectively given freeze ablation，CIK biological therapy and freeze ablation combined with CIK biological therapy.The postoperative result in three groups were evaluated.Results After treatment，the liver metastasis from colon cancer decreased obviously compared with pretreatment.The ablation area obvious increased in freeze ablation combined with CIK biological therapy group than simple freeze ablation group and with less residual tissue；the serum CEA decreased than simple CIK biological therapy group，T cell subsets and immunoglobulin increased，and the difference was statistically significant（P＜0.05）.Conclusion Argon helium targeted ablation combined with CIK biological therapy in treating liver metastasis from colon cancer has better effect than simple freeze ablation and simple CIK biological therapy.