鼻咽癌调强放疗中解剖位置变化对剂量分布的影响

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Abstract Objective To research the anatomy changes during intensity-modulated radiation therapy（IMRT）of patients with nasopharyngeal carcinoma（NPC）and its effect on the dose distribution.M ethods Fifteen patientswith NPC treated in tumor hospital of Ganzhou city in Jiangxi province from January to August 2015，at the 16thand 21thradiotherapy CT scanningwere scaned by the same conditions as the initial CT simulation and at the same time CT and CT of the initial registration were repeated.Clinical target volume（GTVnx，GTVnd，CTV1，CTV2）and volume of the endanger organs，change of dose distribution were calculated.Results Compared with the initial CT，Volume of GTVnx were reduced 20.7%and 33.9%at 16thand 21thafter IMRT　（P＜0.05），GTVnd were reduced 31.0%and 45.5%（P＜0.05），CTV1were reduced 3.5% and 6.8%（P＜0.05），CTV2were reduced 6.2%and 9.2%（P＜0.05）；Volume of the left parotid glandswere reduced 22.2% and 33.9%　（P＜0.05），volume of right parotid gland were reduced 23.5%and 34.5%（P＜0.05）.Volume of brain stem and spinal cord was no obvious changes.Compared with the initial plan，at 16thand 21thafter IMRT，D95 of GTVnx was increased-1.7%and-0.6%，D95 of GTVndwas increased 1.9%and-1.2%；Dmean of left parotid gland was increased 2.9，5.0 Gy，Dmean of right parotid gland was increased 3.0，4.6 Gy，brain stem was increased 0.1，0.3 Gy on Dmax，spinal cord increased 0.3，1.4 Gy on Dmax.Conclusion The volume of target and parotid gland during IMRT in NPC are significantly reduce with the increase of treatment dose，except dose of parotid gland increasing significantly，dose distribution of targetGTVnx，GTVnd have notmuch difference，themaximum dose of brain stem and spinal cord slightly increases.

Key words： Nasopharyngeal carcinoma Intensity-modulated radiation therapy Anatomical structure Dose distribution

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	Articles by authors
	LIJin-wei
	XIAO Hai
	WANG Rong
	ZENG Hong-xue
	WUWei-wei

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LIJin-wei,XIAO Hai,WANG Rong, et al. Influence of anatom ical changes on dose distribution in inasopharyngeal carcinoma w ith intensity-modulated radiation therapy[J]. 中国当代医药, 2016, 23(20): 66-68.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I20/66

［2］	Songthong A，Chakkabat C，Kannarunimit D，et al.Efficacy of intensity-modulated radiotherapy with concurrent carboplatin in nasopharyngeal carcinoma［J］.Radiol Oncol，2015，49（2）：155-162.
［4］	WangW，Yang HH，Mi YC，et al.Rules of parotid gland dose variationsand shiftduring intensitymodulated radiation therapy fornasopharyngeal carcinoma［J］.RadiatOncol，2015，10：3.
［5］	中国鼻咽癌临床分期工作委员会.2010鼻咽癌调强放疗靶区及剂量设计指引专家共识［J］.中华放射肿瘤学杂志，2011，20（4）：267-269.
［7］	杨海华，胡炜，丁维军，等.鼻咽癌调强放疗过程中再次计划实施必要性的临床研究［J］.中华放射肿瘤学杂志，2010，19（3）：189-190.
［1］	Wolden SL，Chen WC，Pfister DG，et al.Intensity-modulated radiotherapy（IMRT）for nasopharyngeal carcinima：update of the Memorial Sloan-Kettering experience［J］.Int JRadiat Oncol Biol Phys，2006，64（1）：57-62.
［3］	Zhang X，Li M，Cao J，et al.Dosimetric variations of target volumes and organs at risk in nasopharyngeal carcinoma intensity-modulated radiotherapy［J］.Br J Radiol，2012，85 （2012）：506-513.
［6］	Barker JL，Garden AS，Ang KK，et al.Quantification of volumetric and geometric changes occurring during fractionated radiotherapy for head-and-neck cancer using an integrated CT/linear accelerator system　［J］.Int J Radiat Oncol Biol Phys，2004，59（4）：960-970.
［8］	黄慧娴.鼻咽癌调强放疗期间自适应放疗计划时机的研究［D］.南宁：广西医科大学，2014.
［9］	Beltran M，RamosM，Rovira JJ，etal.Dose variations in tumor volumes and organs at risk during IMRT for head-and-neck cancer［J］.JAppl Clin Med Phys，2012，13（6）：3723-3734.
［10］	Lu J，Ma Y，Chen J，et al.Assessment of annatomical and dosimetric changes by a deformable registration method during the course of intensity-modulated radiotherapy for nasopharyngeal carcinoma［J］.JRadiatRes，2014，55（1）：97-104.
［11］	Wang X，Lu J，Xiong X，et al.Anatomic and dosimetric changes during the treatment course of intensity-modulated radiotherapy for locally advanced nasopharyngeal carcinoma［J］.Med Dosim，2010，35（2）：151-157.
［12］	黄劭敏，邓小武，赵充，等.鼻咽癌调强放疗中解剖结构改变对剂量分布影响研究［J］.中华放射肿瘤学杂志，2010，19（5）：404-408.
［13］	Cheng HC，Wu VW，Ngan RK，et al.A prospective study on volumetric and dosimetric changes during intensity-modulated radiotherapy for nasopharyngeal carcinoma patients ［J］.Radiother Oncol，2012，104（3）：317-323.
［14］	Capelle L，MackenzieM，Field C，etal.Adaptive radiotherapy using helical tomotherapy for head and neck cancer in definitive and postoperative settings：initial results［J］.Clin Oncol，2011，24（3）：208-215.