简易精神状态量表评分正常慢性阻塞性肺疾病患者脑认知功能研究

Abstract
Figure/Table
References (28)
Related Citation (15)

Download: PDF (0 KB) HTML (49 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate whether there is brain cognitive impairment in patients with chronic obstructive pulmonary disease（COPD）whose mini-mental state examination（MMSE）score are normal.Methods Sixty patients with stable COPD whose MMSE score were normal in our hospital and sixty normal controls from the local community from July 2012 to March 2015 were recruited.All subjects were assessed with the montreal cognitive assessment scale（MoCA）including visuospatial and executive function，naming ability，attention，language fluency，abstraction，memory and orientation.The differences of the MoCA scores were analyzed and compared respectively between two groups.Results The MMSE total score，MoCA total score of COPD patients was lower that in normal controls respectively with statistical difference（P＜0.05）.Visuospatial and executive function（P=0.028），naming ability（P=0.024）and memory（P＜0.001）were significantly worse in COPD than normal controls，but there were no significant differences in attention，language fluency，abstraction，orientation.Conclusion There is still brain cognitive impairment of the patients with COPD whose MMSE score are normal.It is better to use MoCA than MMSE screening COPD patients in cognitive impairment.

Key words： Chronic obstructive pulmonary disease（COPD） Mini-mental state examination（MMSE） Montreal cognitive assessment scale（MoCA） Brain cognitive impairment

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Chun-rong
	QIU Shi-jun
	SHEN Bi-xian
	GAO De-hong
	ZOU Li-qiu
	TAN Si-ping
	CHU Qiankun

Cite this article:

WANG Chun-rong,QIU Shi-jun,SHEN Bi-xian, et al. The study of brain cognitive function in patients with chronic obstructive pulmonary disease with normal mini-mental state examination scores[J]. 中国当代医药, 2016, 23(19): 36-39.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I19/36

［1］	Mathers CD，Loncar D.Projections of global mortality and burden of disease from 2002 to 2030［J］.PLoS Med，2006，3 （11）：e442.
［6］	吕志，胡盼盼，胡先纬，等.稳定期慢性阻塞性肺疾病患者的注意功能及其损害机制［J］.中华医学杂志，2012，92 （6）：405-407.
［8］	Dodd JW，Getov SV，Jones PW.Cognitive function in COPD［J］. Eur Respir J，2010，35（4）：913-922.
［10］	杨天和，林建忠，康泰山，等.慢性梗阻性肺部病变患者脑皮质MRI形态学初步研究［J］.磁共振成像，2015，6（1）：21-26.
［13］	陈瑜，徐传磊.稳定期慢性阻塞性肺疾病患者的工作记忆缺陷［J］.临床肺科杂志，2013，18（7）：1193-1195.
［2］	Ihara M，Okamoto Y，Takahashi R.Suitability of the montreal cognitive assessment versus the mini-mental state examination in detecting vascular cognitive impairment［J］.J Stroke Cerebrovasc Dis，2013，22（6）：737-741.
［3］	Abdool-Gaffar MS，Ambaram A，Ainslie GM，et al.Guideline for the management of chronic obstructive pulmonary disease——2011 update［J］.S Afr Med J，2011，101（1 Pt 2）：63-73.
［4］	Wong GK，Ngai K，Lam SW，et al.Validity of the montreal cognitive assessment for traumatic brain injury patients withintracranial haemorrhage［J］.Brain Inj，2013，27（4）：394-398.
［5］	Crisan AF，Oancea C，Timar B，et al.Cognitive impairment in chronic obstructive pulmonary disease［J］.PLoS One，2014，9（7）：e102468.
［7］	Joo EY，Tae WS，Lee MJ，et al.Reduced brain gray matter concentration in patients with obstructive sleep apnea syndrome［J］.Sleep，2010，33（2）：235-241.
［9］	Chen J，Lin IT，Zhang H，et al.Reduced cortical thickness，surface area in patients with chronic obstructive pulmonary disease：a surface-based morphometry and neuropsychological study［J］.Brain Imaging Behav，2016，10（2）：464-476.
［11］	Morrell MJ，Jackson ML，Twigg GL，et al.Changes in brain morphology in patients with obstructive sleep apnoea［J］. Thorax，2010，65（10）：908-914.
［12］	Dal Negro RW，Bonadiman L，Bricolo FP，et al.Cognitive dysfunction in severe chronic obstructive pulmonary disease（COPD）with or without long-term oxygen therapy （LTOT）［J］.Multidiscip Respir Med，2015，10（1）：1-6.
［14］	Sinha S，Kumar V，Jagannathan NR，et al.Proton magnetic resonance spectroscopy of brain to study the cerebral metabolic abnormalities in COPD patients：a case control study in north India［J］.Indian J Chest Dis Allied Sci，2009，51（1）：15-19.
［15］	Ortapamuk H，Naldoken S.Brain perfusion abnormalities in chronic obstructive pulmonary disease：comparison with cognitive impairment［J］.Ann Nucl Med，2006，20（2）：99-106.
［16］	周文波，金蕊贤，张思义，等.慢性阻塞性肺疾病患者局部大脑血流量分析［J］.海军医学，1997，15（1）：60-62.
［17］	MiyamotoO，AuerRN.Hypoxia，hyperoxia，ischemia，and brain necrosis［J］.Neurology，2000，54（2）：362-371.
［18］	Antonelli-Incalzi R，Corsonello A，Trojano L，et al.Screening of cognitive impairment in chronic obstructive pulmonary disease［J］.Dement Geriatr Cogn Disord，2007，23（4）：264-270.
［19］	Brusselle GG，Joos GF，Bracke KR.New insights into the immunology of chronic obstructive pulmonary disease［J］. Lancet，2011，378（9795）：1015-1026.
［20］	Baumgart M，Snyder HM，Carrillo MC，et al.Summary of the evidence on modifiable risk factors for cognitive decline and dementia：a population-based perspective［J］. Alzheimers Dement，2015，11（6）：718-726.
［21］	Vidal JS，Aspelund T，Jonsdottir MK，et al.Pulmonary function impairment may be an early risk factor for late-life cognitive impairment［J］.J Am Geriatr Soc，2013，61（1）：79-83.
［22］	Lahousse L，Tiemeier H，Ikram MA，et al.Chronic obstructive pulmonary disease and cerebrovascular disease：a comprehensive review［J］.Respir Med，2015，109（11）：1371-1380.
［23］	Bu XL，Cao GQ，Shen LL，et al.Serum amyloid-beta levels are increased in patients with chronic obstructive pulmonary disease［J］.Neurotox Res，2015，28（4）：346-351.
［24］	Barnes PJ，Celli BR.Systemic manifestations and comorbidities of COPD［J］.Eur Respir J，2009，33（5）：1165-1185.
［25］	Barnes PJ.Chronic obstructive pulmonary disease：effects beyond the lungs［J］.PLoS Med，2010，7（3）：e1000220.
［26］	Pendlebury ST，Markwick A，De Jager CA，et al.Differences in cognitive profile between TIA，stroke and elderly memory research subjects：a comparison of the MMSE and MoCA［J］.Cerebrovasc Dis，2012，34（1）：48-54.
［27］	Dodd JW，Chung AW，Van Den Broek MD，et al.Brain structure and function in chronic obstructive pulmonary disease：a multimodal cranial magnetic resonance imaging study［J］.Am J Respir Crit Care Med，2012，186（3）：240-245.
［28］	Zhang H，Wang X，Lin J，et al.Reduced regional gray matter volume in patients with chronic obstructive pulmonary disease：a voxel-based morphometry study［J］.AJNR Am J Neuroradiol，2013，34（2）：334-339.