酒精性肝硬化患者血清脂肪因子的临床意义分析

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Abstract Objective To investigate the clinical significance of serum adipocyte factors in patients with alcoholic cirrhosis.Methods 52 patients with alcoholic cirrhosis from March 2014 to March 2016 in the Central Hospital of Cangzhou City were selected as liver cirrhosis group,among which 17 cases of class A of Child-Pugh grading,20 patients with class B,15 cases of grade C;and 32 healthy controls were selected as control group at the same time.Levels of serum omentin,adiponectin,visfatin and other related clinical and biochemical parameters were measured and compared between patients with liver cirrhosis,different Child-Pugh class of liver cirrhosis and control group.Spearman rank correlation analysis and equation of linear regression were used to analyzed the relationship between cirrhosis serum fat factors and the related biochemical indicators of patients with alcoholic liver.Results The levels of serum omentin and adiponectin in the liver cirrhosis group[(925.19±167.58)ng/L,(908.06±156.96)μg/L]were significantly higher than those of the control group[(793.68±100.38)ng/L,(649.97±105.01)μg/L](P<0.05),level of serum visfatin in the liver cirrhosis group[(18.61±3.75)μg/L]was significantly lower than that of the control group[(23.39±6.15)μg/L] (P<0.05).The levels of serum omentin,adiponectin,visfatin of patients with different Child-Pugh grading of liver cirrhosis had no statistically significant difference(P>0.05).As the increase of Child-Pugh grading,the levels of group of insulin resistance index and IL-6 increased gradually in patients of the liver cirrhosis group(P<0.05).Correlation analysis results show that,there was no significant correlation between the levels of adiponectin,omentin,visfatin and insulin resistance index in the liver cirrhosis group.Conclusion The levels of serum adiponectin,omentin evidently increase and the level of serum visfatin decrease in patients with alcoholic cirrhosis,and can be a prediction index of liver cirrhosis,but which can’t be use to evaluate the degree of liver cirrhosis.

Key words： Alcoholic cirrhosis Omentin Adiponectin Visfatin Child-Pugh grading Insulin resistance

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	Articles by authors
	WEI Xin-liang
	WEI Si-chen
	TIAN Shu-ying
	KONG Yu
	WANG Wei-wei
	JIANG Hong-yu

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WEI Xin-liang,WEI Si-chen,TIAN Shu-ying, et al. Analysis of clinical significance of serum adipocyte factors of patients with alcoholic cirrhosis[J]. 中国当代医药, 2016, 23(31): 18-20转42.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I31/18

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