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Clinical study of different dose of Rosuvastatin for elderly patients with coronary artery borderline lesion |
YUAN Shan-bin1 WU Yong-hua2 GAN Guang-ping1 |
1.Department of Emergency and Critical Care Medicine,Xinfeng County People′s Hospital in Jiangxi Province,Xinfeng 341600,China;
2.Department of Science and Education,Xinfeng County People′s Hospital in Jiangxi Province,Xinfeng 341600,China |
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Abstract Objective To explore the clinical effect of different dose of Rosuvastatin for elderly patients with coronary artery borderline lesion.Methods 220 elderly patients with coronary artery borderline lesion treated by our hospital from May 2014 to May 2015 were selected and they were randomly divided into the two groups.The observation group (111 patients)was treated by high-dose of Rosuvastatin,while the control group(109 patients)was treated by small dose of Rosuvastatin.Clinical symptom remission rate,incidence rate of adverse reactions and IMT of carotid and TG,HDL-C, hs-CRP,LDL-C,TC level in patients between two groups was compared respectively.Results IMT value[(1.36±0.05)cm], incidence rate of adverse reactions(0.90%),and TG value[(0.32±0.05)mmol/L],HDL-C value[(1.89±1.85)mmol/L], hs-CRP value[(9.06±1.42)μg/L],LDL-C value[(0.30±0.08)mmol/L]and TC value[(1.78±0.32)mmol/L]after treatment in observation group was obviously better than that of control group[(2.36±0.98)cm,29.36%,(1.54±0.65)mmol/L, (1.02±0.69)mmol/L,(13.47±4.25)μg/L,(1.36±1.47)mmol/L,(1.57±0.04)mmol/L]respectively(P<0.05).Conclusion High dose of Rosuvastatin for elderly patients with coronary artery borderline lesion is more significant.
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[1] |
王小红,徐军,李丽,等.CTCA对瑞舒伐他汀强化降脂逆转冠状动脉斑块评价的临床应用[J].中国老年学杂志,2015,35(14):3866-3867.
|
[2] |
张北玉,刘灿君,孙爽,等.瑞舒伐他汀早期干预治疗对急性心肌梗死患者行急诊经皮冠状动脉介入治疗中冠状动脉血流的影响[J].中国循环杂志,2013,28(4):270-273.
|
[3] |
Girerd N,Pibarot P,Daleau P,et al.Statins reduce shortand long-term mortality associated with postoperative atrial fibrillation after coronary artery bypass grafting:impact of postoperative atrial fibrillation and statin therapy on survival[J].Clin Cardiol,2012,35(7):430-436.
|
[4] |
许丽华,闻子叶.瑞舒伐他汀降低急性冠状动脉综合征患者冠状动脉支架内再狭窄率[J].中国老年学杂志,2016,36(1):83-85.
|
[5] |
姜海兵,李岚,李秀芬,等.瑞舒伐他汀和氟伐他汀治疗急性冠状动脉综合征合并糖耐量减低患者的疗效观察[J].中国循环杂志,2014,39(7):505-508.
|
[6] |
Kereiakes DJ,Robinson JG,Cannon CP,et al.Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab among high cardiovascular risk patients on maximally tolerated statin therapy:the ODYSSEY COMBOⅠstudy[J].Am Heart J,2015,169(6):906-915.
|
[7] |
黄敏,夏中华,谢福生,等.比索洛尔联合瑞舒伐他汀对冠状动脉慢血流患者内皮功能及炎症的影响[J].天津医药,2016,44(9):1139-1143.
|
[8] |
刘兆奕,刘丽敏.急性冠状动脉综合征患者支架植入术后炎症因子变化及瑞舒伐他汀的干预作用[J].临床荟萃,2013,28(1):14-16,19.
|
[9] |
马晓峰,高琴,边惠萍,等.瑞舒伐他汀对经皮冠状动脉介入治疗患者术后炎症反应与心肌损伤的影响[J].临床荟萃,2013,28(9):1042-1044.
|
[10] |
林泽鹏,舒平春,廖志坚,等.瑞舒伐他汀对急性ST段抬高型心肌梗死患者经皮冠状动脉介入治疗后存活心肌功能及动脉粥样硬化的影响[J].南方医科大学学报,2011,31(10):1789-1791.
|
[11] |
谢文超,李平,王正东,等.不同剂量瑞舒伐他汀对不稳定性心绞痛患者支架置入术后心肌损伤的保护和抗炎作用[J].中国老年学杂志,2015,35(23):6727-6729.
|
[12] |
齐洁,王小飞,王蕾.经皮冠状动脉介入术前单次负荷剂量与常规剂量瑞舒伐他汀对老年冠心病患者预后影响的比较[J].中国中西医结合急救杂志,2015,22(6):606-610.
|
[13] |
吴向军,王庆元,刘海涛.瑞舒伐他汀强化治疗对心肌梗死患者经皮冠状动脉介入术后脂联素和脑钠肽及左心室重构的影响[J].中国医药,2014,9(1):9-13.
|
[14] |
陈杰.瑞舒伐他汀预防冠状动脉支架术后再狭窄的疗效及其对血脂和CRP的影响[J].医学综述,2014,20(20):3816-3817.
|
[15] |
王芳,吴红玲,黄镇河,等.瑞舒伐他汀对冠状动脉血流缓慢的糖尿病患者冠状动脉血流储备的影响[J].中国医药导报,2012,9(4):46-48.
|
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