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| Value of serum high-sensitivity C reactive protein,immunoglobulin and Mycoplasma Pneumoniae DNA in diagnosis of children with Mycoplasma pneumonia |
| GUO Rui-xue |
| Department of Pediatrics,Central Hospital of Longhua District in Guangdong Province,Shenzhen518110,China |
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Abstract Objective To investigate the value of serum high-sensitivity C reactive protein(hs-CRP),immunoglobulin and Mycoplasma Pneumoniae DNA(MP-DNA)in diagnosis of children with Mycoplasma pneumonia(MPP).Methods Altogether 120 children confirmedly diagnosed with MPP who were hospitalized from January 2013 to January 2016 in department of pediatrics in our hospital were selected as MPP group;30 healthy children who were treated in department of outpatient in our hospital at the same period of time were selected as control group;the levels of serum hs-CRP,immunoglobulin(IgA,IgG,IgM etc.)and MP-DNA of the two groups were detected and compared.Results The levels of hs-CRP and MP-DNA of patients in MPP group were higher than those in control group,with statistically significant difference(P＜0.05);the levels of IgA,IgG and IgM of child patients in MPP group were lower than those in control group,with statistically significant difference(P＜0.05).The ROC curve showed the area under hs-CRP curve was 0.776,when the optimal threshold value was 8.18 mg/L,the sensitivity and specificity in diagnosis of MPP were 0.724 and 0.862;as for the combined detection of IgA+IgG+IgM,the area under curve was 0.778,the optimal threshold was 2.68 mg/L,the diagnostic sensitivity and specificity of MPP were 0.808 and 0.694;the area under the MP-DNA curve was 0.751,the optimal threshold was 7.56×105copy/mL,the diagnostic sensitivity and specificity of MPP were 0.769 and 0.781.Conclusion Combination application of hs-CRP,immunoglobulin and MP-DNA in detection of patients with MPP is of high value in early diagnosis.
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