神经节苷脂防治奥沙利铂周围神经毒性临床观察

Abstract
Figure/Table
References (15)
Related Citation (6)

Download: PDF (0 KB) HTML (33 KB)
Export: BibTeX | EndNote (RIS)

Abstract ObjectiveTo observe the efficacy of ganglioside in preventing and reducing chronic sensory neurotoxicity of oxaliplatin.Methods78 patients after gastric and colonrectal cancer resection from July 2014 to July 2016 of Department of Oncology,receiving oxaliplatin-based chemotherapy were divided into treatment group(n=40)and control group (n=38),the treatment group was given the ganglioside at the same time in each cycle of Oxaliplatin chemotherapy,the control group was used furan thiamine in each cycle of chemotherapy at the same time.21 days for a cycle in two groups.After chemotherapy,the neurotoxity evaluation,chemotherapeutic effect and adverse reactions were performed and compared.ResultsThere was noⅣ magnitude peripheral nerve toxicity in the two groups.TheⅡ andⅢ incidence of The peripheral nerve toxicity of experimental group was lower than that of control group(P＜0.05).The total effective rate of chemotherapy,the incidence of chemotherapy related adverse reactions,disease control rate,the median progressionfree surial were compared,there was no statistically significant difference（P＞0.05）.ConclusionGanglioside has better prevent the toxic effects of oxaliplatin into caused by peripheral nerve,and does not affect the curative effect of chemotherapy has not increased treatment-related adverse reactions.

Key words： Periphery neurotoxicity Monosialoganglioside Oxaliplatin

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YANG Hong-shan
	LI Jun
	JIA Xiao-yan

Cite this article:

YANG Hong-shan,LI Jun,JIA Xiao-yan. Efficacy of ganglioside in preventing and reducing chronic sensory neurotoxicity of Oxaliplatin[J]. 中国当代医药, 2017, 24(6): 80-82.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I6/80

[1]	Levi F，Misset JL，Brienza S，et al.A chronopharmacologic phaseⅡ clinical trial with 5-fluorouracil，folinic acid，and oxaliplatin using an ambulatory multichannel programmable pump.High antitumor effectiveness against metastatic colorectal cancer[J].Cancer，1992，69（4）：893-900.
[2]	孙燕.内科肿瘤学[M].北京：人民卫生出版社，2001：995.
[3]	朱成功，刘丽丽，冯仲珉，等.奥沙利铂联合替吉奥治疗晚期胃癌的效果[J].中国当代医药，2014，21（33）：60-62.
[4]	傅伟伟.以奥沙利铂为主的化疗所致神经损害的护理体会[J].中国当代医药，2009，16（16）：192.
[7]	刘素，张侠.奥沙利铂神经毒性机制及基因多态性研究进展[J].中华临床医师杂志，2015，9（9）：163-167.
[12]	张淋坤，张引成.神经生长因子和神经节苷脂的研究进展[J].中国实用神经疾病杂志，2010，13（10）：89-93.
[5]	Park SB，Goldstein D，Lin CS，et al.Acute abnormalities sensory nerve function associated with oxaliplatin-induce neurotoxicity[J].Clin Oncol，2009，27（8）：1243-1249.
[6]	Van Cutsem E，Nordlinger B，Cervantes A.Advanced colorectal cancer：ESMO Clinical Practice Guidelines for treatment[J].Ann Oncol，2010，21（Suppl 5）：93-97.
[8]	Grolleau F，Gamelin L，Boisdron-Celle M，et al.A possible explanation for a neurotoxic effect of the anticancer agentox aliplatin on neuronal voltage-gated sodium channels[J].Neurophysiol，2001，85（5）：2293-2297.
[9]	Grothey A，Nikcevich DA，Sloan JA，et al.Intravenous calcium and magnesium for oxaliplatin-induced sensoty neurotoxicity in adjuvant colon cancer：NCCTG N04C7[J].J Clin Oncol，2011，29（4）：421-427.
[10]	Hochster HS，Grothey A，Childs BH.Use of calcium and magnesium salts to reduce oxaliplatin-related neurotoxicity [J].J Clin Oncol，2007，25（25）：4028-4029.
[11]	Ning N，Chen NH.Progress in the research of Ganglioside′s biological activities[J].Sheng Li Ke Xue Jin Zhan，2009，40（1）：24-30.
[13]	Adelsberger H，Quasthoff S，Grosskreutz J，et al.The chemotherapeuticoxaliplatin alters voltage-gated Na（+）channel kinetics on rat sensory neutons[J].Eur J Pharmacol，2000，406（1）：25-32.
[14]	Kurniali PC，Luo LG，Weitberg AB.Role of calcium/magnesium infusion in oxaliplatin-based chemotherapy for colorectal cancer patients[J].Oncology，2010，24（3）：289-292.
[15]	Zhang XL，Shi HJ，Cui SZ，et al.Prospective，randomized trial comparing 5-FU/LV with or without oxaliplatin as adjuvant treatment following curative resection of gastric adenocaicinoma[J].Eur J Surg Oncol，2011，37（6）：466-472.