IMP3、Ki-67在胃肠胰神经分泌肿瘤中的表达及与临床病理特征的关系

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Abstract ObjectiveTo investigate the expression of IMP3 and Ki-67 in gastrointestinalopancreatic neuroendocrine neoplasm(GEP-NEN)and its relationship with clinicopathological features.Methods59 patients with GEP-NEN diagnosed from January 2010 to October 2016 in our hospital and other surrounding areas were collected.Immunohistochemistry was used to detect the expression of IMP3 and Ki-67 in patients′specimens.Clinical and pathological features were combined,and the results were statistically analyzed.ResultsThe positive rate of IMP3 in GEP-NEN was 81.36%(48/ 59).The differences of the expression in different tumor size,whether there was lymph node metastasis or not,different tumor stages and classifications were statistically significant(P＜0.05).There was no statistical significance in the expression of tumor in terms of whether there was distant metastasis or not(P＞0.05).The positive rate of Ki-67 in GEPNEN was 44.68% (26/59).The differences of the expression in different tumor size,whether there was lymph node metastasis or not,whether there was distant metastasis or not,different pathological grades and clinical stages were statistically significant(P＜0.01);the positive rate of the expression of IMP3 and Ki-67 was increased with larger tumor size,lymph node metastasis,higher pathological grades,and more advanced clinical stages.ConclusionThe expression of IMP3 and Ki-67 in GEP-NEN may be one of the reference factors for determining patients′prognosis.IMP3 may play an important role in the development and progression of GEP-NEN.

Key words： Neuroendocrine neoplasm Insulin-like growth factorⅡmRNA binding protein 3 Cell proliferating nuclear antigen

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	LI You-heng
	XU Hong
	ZENG Xun

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LI You-heng,XU Hong,ZENG Xun. Expression of IMP3 and Ki-67 in gastroenteropancreatic neuroendocrine neoplasm and its relationship with clinicopathological features[J]. 中国当代医药, 2017, 24(6): 15-18.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I6/15

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