低分子肝素对脓毒症大鼠肝损伤保护作用的实验研究

Abstract
Figure/Table
References (15)
Related Citation (15)

Download: PDF (0 KB) HTML (42 KB)
Export: BibTeX | EndNote (RIS)

Abstract ObjectiveTo explore the protective effect and mechanism of low molecular weight heparin in liver injury of septic rats.Methods50 male SD rats were randomly divided into control group (10 cases),model group (20 cases)and treatment group(20 cases).Cecal ligation puncture(CLP)was used to made sepsis model.Rats in model group were given tail vein injection saline,and the treatment group was given tail vein injection low molecular weight heparin.The level of serum alanine aminotransferase (ALT),aspartate aminotransferase (AST),prothrombin time (PT),activated partial thromboplastin time(APTT),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)of rats′serum was detected at different time points,and histopathological changes of liver were observed at 12 h.ResultsCompared with control group, the level of serum ALT,AST,PT,APTT,TNF-αand IL-6 in model group and treatment group at different time points were obviously increased (P＜0.01).Compared with model group,the level of serum ALT,AST,PT,APTT,TNF-α and IL-6 in treatment group at different time points(6 and 12 h)were decreased (P＜0.05).Histopathological changes of liver at 12 h in treatment group obviously improved than model group.ConclusionLow molecular weight heparin has protective effect on liver damage of septic rats,the mechanism may be related to anticoagulation and inhibition of release of inflammatory factors.

Key words： Low molecular weight heparin Sepsis Liver injury Inflammatory factor

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	PAN Yi
	HE Fei-min
	CHEN Jun-xi
	XIA Zhi-hui
	YAN Zhi-jie
	WU Li-li
	CHENG Ying

Cite this article:

PAN Yi,HE Fei-min,CHEN Jun-xi, et al. Experimental study of protective effect of low molecular weight heparin on hepatic injury induced by sepsis in rat[J]. 中国当代医药, 2017, 24(6): 7-10.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I6/7

[1]	吴孟超，李梦东.实用肝病学[M].北京：人民卫生出版社，2011：23-59.
[2]	姚咏明.现代脓毒症理论与实践[M].北京：科学出版社，2005：623-627.
[3]	陈智，朱海红，杨英．细胞因子风暴与肝衰竭[J].临床肝胆病杂志，2014，30（10）：981-983．
[4]	马思远，张雅萍．肠源性内毒素损害防治策略思考[J]．中华烧伤杂志，2011，27（2）：125-127．
[5]	Yang Q，Shi Y，He J，et al.The evolving story of macrophages in acute liver failure[J].Immunol Lett，2012，147（1-2）：1-9.
[6]	Sakaguchi S，Furusawa S.Oxidative stress and septic shock：metabolic aspects of oxygen-derived free radicals generated in the liver during endotox emia[J].FEMS Immunol Med Microbiol，2006，47（2）：167-177.
[7]	Schiff ER，Maddrey WC，Sorrell M.希夫肝脏病学[M].11版.王福生,译.北京：北京大学医学出版社，2015：849-851.
[8]	Albuszies G，Radermacher P，Vogt J，et al.Effect of increased cardiac output on hepatic and intestinal microcirculatory blood flow，oxygenation，and metabolism in hyperdynamic murine septic shock[J].Crit Care Med，2005，33（10）：2332-2338.
[9]	马晓春．应重视脓毒症的抗凝治疗[J].中国危重病急救医学，2010，22（9）：516－517．
[10]	Napoleone，Di Santo A，Bastone A，et al.Long pentraxin PTX3 up regulates tissue factor expression in human endothelial cells：a novel link between vascular inflammation and clotting activation[J].Arterio Scler Thromb Vasc Biol，2002，22（5）：782-787.
[14]	Boos CJ，Goon PK，Lip GY.The endothelium，inflammation，and coagulation in sepsis[J].Clin Pharmacol Ther，2006，79（1）：20-22.
[15]	马晓春.应加深对脓毒微循环功能障碍的认识[J].中国危重病急救医学，2011，23（2）：66.
[11]	Tymi K.Critical role for oxidative stress platelets and coagulation in capillary blood flow impairment in sepsis[J].Microcirculation，2011，18（2）：152-162.
[12]	Comet AD，Smit EG，Beishuizen A，et al.The role of heparin and allied compounds in the treatment of sepsis[J].Thromh Haernoat，2007，98（3）：579-586.
[13]	Clemens F，Christian JW.Effects of anticoagulant strategies on activation of inflammation and coagulation[J].Expert Op in Biol Ther，2007，7（6）：855-870.