合并2型糖尿病行冠脉搭桥手术患者临床预后的Meta分析

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Abstract Objective To investigate the mortality(30 days,1 year,3,5,10 years)and relative risk(RR)of patients undergoing coronary artery bypass grafting(CABG)for diabetics mellitus(DM)and non-diabetics mellitus(NDM).Methods By refering to relevant DM guidelines for inclusion criteria and exclusion criteria,search strategies were made out.Afterwards,Pubmed, EMBase,Cochrane library,SinoMed,CNKI,WanFang&VIP databases were searched for literatures published from January 1981 to December 2016.Subsequently,Meta analysis was used to investigate the mortality and relative risk(RR)of patients with DM and NDM after 30 days,1 year,3,5,10 years.A quality assessment scale was developed to identify each potentially qualified document,moderate and high quality documents were selected for data extraction&meta-analysis.RevMan5.3 software was used for statistical analysis.Results 28 eligible documents were identified for pooled analysis.The pooling mortality of 30 days,1 year,3,5,10 years for DM group and NDM group was 2.65%,1.92%;5.21%,3.23%;10.15%,5.86%;16.88%, 11.20%;23.12%,21.40%.The pooled RR(95%CI)for mortality rate of DM group versus NDM group were significantly increased at 30 days[1.50(1.34,1.68)],1 year[1.88(1.59,2.22)],3 years[1.74(1.53,1.99)]and 5 years[1.52(1.34,1.73)]after CABG(P＜0.01). 10 years mortality was failed to make pooled analysis due to obvious heterogeneity(I2＞70%).Conclusion The pooling data indicates that CABG may considerably increase mortality risk of 30 days,1 year,3,5,10 years in DM compared to NDM.

Key words： Coronary artery bypass grafting T2DM Prognosis Meta-analysis

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	WU Zhi-guo
	LIN Li-chang
	TAN Jian
	PENG Hong

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WU Zhi-guo,LIN Li-chang,TAN Jian, et al. Meta analysis of clinical outcomes in patients with type 2 diabetes undergoing coronary artery bypass grafting[J]. 中国当代医药, 2017, 24(7): 4-10转15.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I7/4

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