癫痫伴情绪障碍者相关影响因素分析

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Abstract Objective To investigate the related influence factors of epilepsy complicated with mood disorder.Methods Altogether 60 epilepsy patients treated in outpatient department of neurology of Brain Hospital of Guangxi Zhuang Autonomous Region from January 2014 to December 2015 were involved as epilepsy group,and 50 cases of healthy persons who accepted health examinations at the same period was involved as control group.The general conditions,the clinical features,self-rating depression scale(SDS)and the self-rating anxiety scale(SAS)of two groups were observed.Pearson correlation analysis of SDS,SAS and clinical features and Logistic regression analysis of SDS and SAS of two groups were also observed.Results Two groups had no significant difference in gender,marital status and educational background(P＞0.05).The proportion of relatively low brain 5-HT power was lower than that of normal brain 5-HT power,the proportion of seizure frequency≤2 times/year was higher than that＞2 times/year,and the proportion of use of＞2 antiepileptic drugs was higher than that of single drug(χ2=48.74,50.00,22.31，P＜0.05).SDS and SAS score of epilepsy group were higher than those of control group(t=11.50,12.36,P＜0.05).Epilepsy patients′SAS score showed a positive correlation with the number of antiepileptic drugs(r=0.328,P＜0.05),and SDS score was positively correlated with seizure frequency and course of disease,negatively correlated with brain 5-HT power(r=0.209,0.214,-0.189,P＜0.05);the number of antiepileptic drugs was the influencing factors of epilepsy patients′anxiety(χ2=11.024,P＜0.01);and the seizure frequency,course of disease,brain 5-HT power were the influence factors of epilepsy patients′depression(χ2=10.697,10.789,-11.052,P＜0.01),with statistically significant difference.Conclusion The more antiepileptic drugs the epilepsy patients take,the more possibility the anxiety will occur;the more epilepsy seizures,the longer course of disease,the lower brain 5-HT power,the more possibility the depression will occur.

Key words： Epilepsy Depression Anxiety Related factors

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	HUANG Bo
	LI Chun

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HUANG Bo,LI Chun. Analysis of related factors of epilepsy complicated with mood disorder[J]. 中国当代医药, 2017, 24(10): 56-58转61.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I10/56

[1]	Ochoa-Gomez L，Lopez-Pison J，Fernando-Martinez R，et al.A descriptive study of non-symptomatic epilepsy according to age at onset at a neuropediatric section of regional reference[J].Rev Neurol，2016，63（10）：447-454.
[2]	Lee YK，Ah YM，Choi YJ.Antiepileptic drug adherence and persistence in children with epilepsy attending a large tertiary care children′s hospital[J].Epileptic Disord，2016，53（10）：448-449.
[3]	单峤，王世勋，王新军，等.老年癫痫患者手术治疗预后的相关影响因素[J].中国老年学杂志，2014，34（8）：2142-2143.
[4]	Choikwon S，Chung C，Kimh，et al.Factors affectiong thequality of life in patients with epilepsy in Seoul，South Korea[J].Acta Neurol Scand，2003，108（6）：428-434.
[5]	International League Against Epilepsy（ILAE）.国际抗癫痫联盟委员会关于癫痫发作和癫痫诊断方案的建议[J].中华神经科杂志，2003，36（4）：302-307.
[6]	舒良.自评抑郁量表[J].中国心理卫生杂志，1999，（增刊）：194-196.
[7]	吴文源.焦虑自评量表[J].中国心理卫生杂志，1999，（增刊）：235-238.
[8]	曾远明，李长清，胡常林.脑电超慢涨落图的正常参考值[J].现代医药卫生，2004，20（15）：1522.
[9]	Cavanna AE，Cavanna S，Bertero L，et al.Depression in women with epilepsy：clinical and neurobiologieal aspects[J].Funet Neurol，2009，24（2）：83-87.
[10]	McLean CP，Asnaani A Litz BT et al.Gender differences in anxiety disorders：prevalence，course of illness，comorbidity and burden of illness[J].J Psychiatric Res，2011，45（8）：1027-1035.
[11]	Caboclo LO，Neves RS，Jardim AP，et al.Surgical and postmortem pathology studies：contribution for the investigation of temporal lobe epilepsy[J].Arq Neuropsiquiatr，2012，70（12）：945-952.
[12]	Bulteau C，Otsuki T，Delalande O.Epilepsy surgery for hemisphericsyndromesininfants：hemimegalencepahlyandhemispheric cortical dysplasia[J].Brain Dev，2013，7604（13）：167-168.
[13]	HauptmanJS，DadoutA，OhT，etal.Sociodemographicchanges over 25 years of pediatric epilepsy surgery at UCLA[J].J Neurosurg Pediatr，2013，11（3）：250-255.
[14]	Yasuda CL，Cendes F.Neuroimaging for prediction of response to medical and surgical treatment in epilepsy[J].Expery Opin Med Diagn，2012，6（4）：295-308.
[15]	Dias R，Lisa M，Sarah B，et al.Farias Depression in epilepsy is associated with lack of seizure control[J].Epilepsy Behav，2010，19（12）：445-447.
[16]	Thapar A，Roland M，Harold G.Do depression symptoms prediet seizure frequency-or vice versa？[J]Psychosom Res，2005，59（5）：269-274.
[17]	常亮，常婧，石献，等.癫痫患者伴发焦虑状况及其影响因素研究[J].中华流行病学杂志，2012，33（10）：1098-1099.