替米沙坦对老年糖尿病合并高血压患者血清网膜素、白细胞介素-18水平的影响

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Abstract ObjectiveTo study the changes of serum Omentin,IL-17 and IL-18 level,to studay the possible effect of of serum Omentin,IL-17 and IL-18 change in the develpment of hypertension,to investigate the effect of Telmisartan on the level of serum Omentin,IL-17 and IL-18 in the aged diabetic patients with hypertension.Methods126 aged patients with type 2 diabetes mellitus were selected from January 2015 to June 2016 in our hospital,and they were divided into two group:72 cases of type 2 aged diabetic patients with hypertension (diabetic patients with hypertension group) and 54 cases of type 2 aged diabetic patients with normal blood pressure (diabetic patients with normal blood pressure group).30 cases of normal aged individuals with physical examination during the same period were as the control group (control group).The level of serum Omentin,IL-17 and IL-18 were measured in the three groups.The relatoinshp between the serum Omentin level and serum IL-17,IL-18 level were analyzed in the aged diabetic patients with hypertension.The change of seroum Omentin,IL-17and IL-18 level were investigated in the aged diabetic patients with hypertension after treatment with Telmisartan.ResultsSerum Omentin level in the aged diabetic patients with hypertension group was significantly lower than those in the diabetic patients with normal blood pressure group,the serum IL-17 and IL-18 level in the aged diabetic patients with hypertension group were significantly higher than those in the aged diabetic patients with normal bloodpressure group,the differences were statistically significant(P＜0.01).A negtive correlation was found between serum Omentin level and serum IL-17,IL-18 level in the aged diabetic patients with hypertension group (r=-0.527,r=-0.602, P＜0.01).Serum Omentin level was significantly increased,the levels of IL-17 and IL-18 were significantly decreased after treatment with Telmisartan in the aged diabetic patients with hypertension group,the differences were statistically significant(P＜0.01).ConclusionThe low serum level of Omentin and increased serum level of IL-17,IL-18 might play an important role in the development of hypertension in the aged diabetic patients.The serum Omentin level was significantly increased,the level of IL-17 and IL-18 were significantly decreased after treatment with Telmisartan in the aged diabetic patients with hypertension.

Key words： Type 2 diabetic patient Hypertension Omentin IL-17 IL-18

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	Articles by authors
	LI Zhao-lei
	YUE Wei
	WANG Hong
	SUN Wei
	CUI Qiu-zi
	CHAI Guo-lu

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LI Zhao-lei,YUE Wei,WANG Hong, et al. Effect of Telmisartan on the level of serum Omentin and IL-18 in the aged diabetic patients with hypertesion[J]. 中国当代医药, 2017, 24(14): 52-55.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I14/52

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