同源基因IRX1在原发性肝癌中的表达及其临床意义

Abstract
Figure/Table
References (16)
Related Citation (4)

Download: PDF (0 KB) HTML (33 KB)
Export: BibTeX | EndNote (RIS)

Abstract ObjectiveTo explore the expression and clinical significance of homologous gene IRX1 in primary hepatocellular carcinoma.Methods30 patients with liver cancer who were treated by operation in People′s Hospital of Guangming New District in Shenzhen City and Shiyan People′s Hospital of Shenzhen City from May 2014 to May 2016 were selected as observation group,at the same period,30 volunteers or patients with benign liver diseases were selected as control group.Detection of mRNA transcription level and detection of IRX1 protein expression in liver tissue after IRX1 gene was prepared,and the differences of IRX1 expression were compared between the two groups.ResultsThe expression and transcription level of IRX1 protein in the liver tissue of the control group were significantly different from that of the control group (P<0.05).In the observation group,the expression of IRX1 protein in high,middle and low differentiation was 1.90 times,3.31 times and 3.33 times of control group respectively.In the observation group,high,middle and low differentiation transcription level was 2.95 times,1.83 times,4.46 times as compared with that in control group,the difference was statistically significant(P<0.05).The positive rate of IRX1 in the observation group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference of complications between the two groups(P>0.05).ConclusionIRX1 is involved in the incidence and devel opment process of hepatocellular carcinoma,and its expression is correlated with the degree of differentiation of liver cancer.IRX1 can be used as an indicator for judge the state of an illness in clinic.

Key words： Primary liver cancer Homologous gene Transcription Expression

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	XU Hai-tao
	LIU Liang-tian
	TANG Yong-hua
	LI Ping

Cite this article:

XU Hai-tao,LIU Liang-tian,TANG Yong-hua, et al. Expression and clinical significance of homologous gene IRX1 in primary hepatocellular carcinoma[J]. 中国当代医药, 2017, 24(14): 4-6.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I14/4

[1]	辛晟梁.介入治疗在原发性肝癌中的应用[J].中国当代医药，2015，22（2）：10-12.
[2]	周亮，王世明.GP73、AFP异质体联合检测在原发性肝癌早期诊断中的应用进展[J].中国当代医药，2015，22（4）：15-17.
[3]	王小峰，王世明，申增强.联合检测肿瘤标志物在原发性肝癌中诊断价值的研究[J].中国当代医药，2014，21（3）：185-187.
[4]	涂艳阳，张鹏幸，张永生，等.IRX1在肿瘤发生发展中的作用研究[J].转化医学电子杂志，2016，3（10）：1-4.
[5]	余爽，王静，董冰，等.IRX2基因在原发性肝癌中表达的初步研究[J].解放军医学杂志，2013，38（3）：185-187.
[6]	Jiang J，Liu W，Guo X，et al．IRX1 influences peritoneal spreading and metastasis via inhibiting BDKRB2-dependent neovascularizationon gastric cancer[J].Oncogene，2011，30 （44）：4498-4508．
[7]	杨华瑜，王绎沈，徐海峰，等.血清AFP、GP73、GPC3单独及联合检测对肝癌的诊断价值[J].癌症进展，2013，11（3）：249-253.
[8]	杨贵敏，杨运强，赵云胜.血清异常凝血酶原，磷脂酰肌醇蛋白聚糖-3联合甲胎蛋白检测在原发性肝癌诊断中的临床意义[J].山西医药杂志，2013，42（7）：783-785.
[9]	覃运荣.5种肿瘤标志物联合检测对原发性肝癌诊断价值的探讨[J].医学检验与临床，2010，21（2）：39-41.
[10]	周志忠，林奎生，叶惠珍，等.HER－2／neu基因在肝癌高发区原发性肝癌表达和意义[J].国际检验医学杂志，2013，34（8）：1354-1356.
[11]	许成新，褚邦勇，徐玖飞，等.甲胎蛋白、甲胎蛋白异质体、铁蛋白和肿瘤相关因子联合检测在原发性肝癌诊断中的价值[J].中国卫生检验杂志，2012，22（2）：308-309，311.
[12]	姚建华.高尔基体蛋白73和甲胎蛋白联检在原发性肝癌诊断中的临床应用[J].放射免疫学杂志，2012，25（6）：673-675.
[13]	黄必军，黄铁军，梁启万，等．应用双色FISH技术检测肝癌中HER－2的定量扩增及其临床意义[J]遗传学报：英文版，2001，28（9）：793-800.
[14]	白雪峰，吴拥军.常用肿瘤标志物在肝癌诊断中的应用现状[J].实用医药杂志，2011，28（5）：473-475.
[15]	龙璐，陈贞，王堃，等.血清GP73、GPC3、AFP-L3和AFP检测对原发性肝癌诊断的价值[J].中国现代医学杂志，2013，23（28）：46-50.
[16]	杨贵敏，杨运强，赵云胜.血清异常凝血酶原，磷脂酰肌醇蛋白聚糖-3联合甲胎蛋白检测在原发性肝癌诊断中的临床意义[J].山西医药杂志，2013，42（7）：783-785.