ObjectiveTo compare the effect of peripheral catheterization(PICC)and subclavian vein implantation in central venous catheters(CVC)in patients with malignant tumor.Methods142 patients with advanced malignant tumor received：chemotherapy in our hospital from from January 2015 to January 2016 were selected and divided into two groups according to random numbers table method,72 patients were given peripheral vein puncture(the observation group),72 patients were given clavicle(the control group).The one-time success rate,catheter indwelling time and incidence of complications were compared were compared between two groups.ResultsThere were no statistically significant differences of one-time success rate(95.8%vs.90.3%),the catheter indwelling time[(70.52±33.54)d vs.(76.01±36.47)d]between two groups(P＞0.05).The incidence of complications in the observation group (9.7%)was lower than that in the control group(22.2%),and the difference was statistically significant(P＜0.05).ConclusionPICC catheterization has a good effect on reducing the incidence of complications in patients with advanced chemotherapy,and it has no adverse effect on the success rate of catheter retention and so on.It is worthy to be popularized.