Objective To explore the application effect of evidence-based nursing model combined with peer support intervention in patients with acute myocardial infarction (AMI).Methods A total of 172 AMI patients admitted to Liwan Central Hospital of Guangzhou from January 2021 to December 2022 were selected as the study subjects.They were divided into a control group(86 cases)and an observation group(86 cases)by a random number table method.The control group received routine care,while the observation group implemented an evidence-based nursing model combined with peer support intervention.Both groups continued to receive care until the patient was discharged.The nursing outcomes (psychological state,self-efficacy,quality of life,nursing satisfaction) were compared between the two groups.Results The scores of self-rating depression scale(SDS)and self-rating anxiety scale(SAS)in the observation group were lower than those in the control group,and the scores of general self-efficacy scale (GSES) were higher than those in the control group,the differences were statistically significant(P＜0.05).The scores of the MOS item short from health survey(SF-36)in the observation group were higher than those in the control group,the difference was statistically significant(P＜0.05).The nursing satisfaction score of observation group was higher than that of control group,and the difference was statistically significant(P＜0.05).Conclusion The evidence-based nursing model combined with peer support intervention can alleviate the negative emotions of AMI patients,effectively enhance their self-efficacy,improve their quality of life,and thus enhance patient satisfaction.