Objective To explore the effect of vestibular rehabilitation training on negative emotions and sleep quality in patients with vestibular migraine(VM).Methods A total of 152 VM patients admitted to the Department of Neurology,Nanchang First Hospital from January 2020 to December 2022 were selected as observation objects,and were divided into control group and observation group according to random number table method,with 76 cases in each group.The control group was treated with western medicine+routine nursing,and the observation group was treated with vestibular rehabilitation training in addition.The scores of dizziness handicap inventory (DHI),the number of attacks,the duration of attacks,the score of Hamilton anxiety scale(HAMA),the score of Hamilton depression scale(HAMD),the visual analogue scale(VAS)of pain,the score of Pittsburgh sleep quality index (PSQI),blood nitric oxide (NO),prostaglandin E2 (PGE2),high-sensitivity C-reactive protein (hs-CRP)levels and intervention satisfaction of the two groups were compared.Results After the intervention,the DHI score of the two groups of patients was lower than before the intervention,the frequency of attacks was less than before the intervention,and the duration of attacks was shorter than before the intervention,and the DHI score of the observation group was lower than the control group,the frequency of attacks was less than the control group,and the duration of attacks was shorter than the control group,the differences were statistically significant (P＜0.05).After the intervention,the HAMA and HAMD scores of the two groups were lower than before the intervention,and the HAMA and HAMD scores of the observation group were lower than those of the control group,with statistical significance(P＜0.05).After intervention,VAS and PSQI scores of the two groups were lower than before intervention,and VAS and PSQI scores of observation group were lower than control group,the differences were statistically significant (P＜0.05).After intervention,the levels of NO,PGE2 and hs-CRP in the two groups were lower than before intervention,and the levels of NO,PGE2 and hs-CRP in observation group were lower than control group,with statistical significance(P＜0.05).The intervention satisfaction of observation group was higher than that of control group,the difference was statistically significant(P＜0.05).Conclusion Vestibular rehabilitation training can alleviate the symptoms of VM patients,reduce the frequency and duration of seizures,improve negative emotions and sleep quality,and increase intervention satisfaction.Its mechanism may be related to regulating the levels of NO,PGE2 and hs-CRP.