analysis between cervical lesions and HPV infection.Methods The Polymerase Chain Reaction (PCR)method was used to examine 13 000 women who underwent cervical cancer screening at Liangzhou Hospital in Wuwei City,Gansu Province,from March 2021 to September 2023.Among the screened individuals,1 200 cases were identified with HPV infection,and they underwent colposcopy and cervical biopsy.Based on the presence or absence of cervical lesions according to cervical tissue biopsy results,the patients were divided into two groups: the lesion group(n=486) and the non-lesion group (n=714).Univariate analysis was used to identify factors influencing the occurrence of cervical lesions,and multivariate logistic regression analysis was employed to analyze factors with P＜0.05 in the univariate analysis.Results The results of univariate analysis showed significant differences between the lesion and non-lesion groups in terms of age,persistent HPV infection,cervical columnar epithelial displacement,number of sexual partners,and HPV infection type(P＜0.05).Multivariateanalysisrevealed thatage ＜25 or ≥55 years(β=0.754,OR=2.126,95%CI:1.649-2.740),persistent HPV infection (β=1.048,OR=2.853,95%CI: 2.209-3.683),cervical columnar epithelial displacement (β=0.625,OR=1.868,95%CI:1.453-2.401),number of sexual partners ≥2 (β=0.625,OR=1.988,95%CI:1.546-2.556)and high-risk HPV infection type(β=0.863,OR=2.371,95%CI:1.833-3.066)were independent risk factors for the occurrence of cervical lesions.Conclusion There is a connection between HPV infection and cervical lesions,with HPV16/HPV18 being the main types of HPV infection associated with cervical lesions.Advocating for regular check-ups and implementing targeted measures for different women are of profound significance for reducing the occurrence of cervical lesions due to HPV infection and preventing cervical cancer.