Objective To explore the correlation between serum levels of late oxidized protein product (AOPP),monocyte chemoattractant protein-1 (MCP-1)and preeclampsia (PE)in pregnant women with gestational diabetes mellitus(GDM).Methods A total of 70 pregnant women with GDM complicated with PE admitted to the obstetrics Department of the Affiliated Hospital for Nationalities of Guangxi Medical University from October 2021 to September 2023 were selected as the combination group,and another 70 pregnant women with simple GDM who came to the Affiliated Hospital for Nationalities,Guangxi Medical University during the same period were selected as the non-combination group.The clinical data and laboratory indicators of the two groups of subjects were statistically analyzed.Multivariate logistic analysis was used to analyze the correlation between AOPP,MCP-1 and GDM complicated with PE.ROC was used to analyze the diagnostic value of serum AOPP and MCP-1 combined detection of GDM complicated with PE.Results Univariate analysis showed that there were statistically significant differences in age,pre-pregnancy body mass index(BMI),serum AOPP and MCP-1 expression levels between the two groups(P＜0.05).Multivariate logistic regression showed that age,pre-pregnancy BMI,serum AOPP and MCP-1 were independent risk factors for GDM complicated with PE(P＜0.05).ROC curve showed that the areas under serum AOPP,MCP-1 and their combined detection curves were 0.867,0.916 and 0.942.Conclusion AOPP and MCP-1 are closely related to the risk of GDM with PE,and have high application value in the diagnosis of the disease.