脑白质高信号患者执行功能与脑血流量的相关性分析

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Abstract

Objective To explore the cerebral perfusion mechanism of executive function in patients with high white matter signal by three-dimensional arterial spin labeling (3D-ASL).Methods A total of 104 patients with high white matter signal were collected from the Department of Neurology of Hongqi Hospital Affiliated to Mudanjiang Medical College from March 2021 to December 2022,the patients were included in the case group,and 52 matched healthy people at the same period were included in the control group.The case group was divided into a mild group(0-2 points)and a moderately severe group(3-6 points) according to the Fazekas classification.Baseline data,neuropsychological assessments including Montreal assessment scale,drawing bell test,and connectedness test were collected from both groups.All subjects underwent routine serial and 3D-ASL examinations,while cerebral blood flow (CBF) values were obtained for each lobe region of interest.Comparisons of differences in executive function and cortical CBF values of individual lobes between case and control groups were performed,and correlations between cortical CBF values and executive function were analysed.Results The CBF of mild group were lower than those of control group in bilateral frontal lobe and thalamus,the CBF in the frontal,parietal,temporal and thalamic lobes in the moderate to severe group were lower than those in the other two groups,and the differences were statistically significant(P＜0.05).There was a positive correlation between left frontal lobe CBF and executive function in mild group(P＜0.05).The CBF values in the left frontal and temporal lobes were positively correlated with executive function (P＜0.05).Conclusions Early decline in executive function may be associated with decreased cerebral blood flow in the left frontal lobe,providing an imaging basis for predicting cognitive decline.

Key words： Executive dysfunction Cerebral white matter high signal Arterial spin labeling Cognitive impairment

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