Objective To observe the effect of advance care planning (ACP) with family follow-up in patients with end-stage lung cancer.Methods A total of 110 patients with end-stage lung cancer admitted to Jiangxi Cancer Hospital from January to December 2022 were selected as the study objects and divided into control group(55 cases)and experimental group(55 cases)by drawing lots.Patients in the control group received routine cancer nursing,and patients in the experimental group received ACP intervention with joint family follow-up.The dignity level,life quality and death quality of the two groups were compared.Results There was no significant difference in scores of psychological status,symptom distress,dependence,mental peace and social support between the two groups before intervention (P＞0.05).The scores of psychological status,symptom disturbance,dependence,mental peace and social support of experimental group were lower than those of control group after intervention,and the differences were statistically significant(P＜0.05).There were no significant differences in the role function scores,physical function scores,cognitive function scores,social function scores and emotional function scores of European Organization for Research and Treatment of Cancer quality of life questionnaire(EORTC QLQ-C30)between the two groups before intervention (P＞0.05).The EORTC QLQ-C30 scores of the two groups after intervention were higher than those of the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in good death inventory (GDI)scores between the two groups before intervention (P＞0.05).The GDI score of experimental group was higher than that of control group after intervention,and the difference was statistically significant (P＜0.05).Conclusion Patients with end-stage lung cancer use the ACP intervention model of combined family follow-up,allowing patients to fully express their willingness to care and end-of-life treatment willingness,and walk through their life journey comfortably.